Acidic Methanol Methylation for HAA Analysis: Limitations and Possible Solutions
Acidic Methanol Methylation for HAA Analysis: Limitations and Possible Solutions
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DOI：
10.1002/j.1551-8833.2002.tb10235.x
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发表时间：
2002-11
期刊：
影响因子：
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通讯作者：
Yuefeng F. Xie;Inni Rashid;Hao Zhou;L. Gammie
中科院分区：
文献类型：
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作者：
Yuefeng F. Xie;Inni Rashid;Hao Zhou;L. Gammie
酸性甲醇甲基化是卤乙酸分析中常用的衍生化方法。位于哈里斯堡的宾夕法尼亚州立大学和位于阿尔塔的埃德蒙顿的EPCOR水务公司，进行了哈斯的酸性甲醇甲基化研究。使用当前的甲基化条件（美国环境保护署方法552.2），作者观察到哈斯的不完全甲基化，尤其是三卤乙酸，这可能会显著影响这些HAA分析结果的准确度。研究了甲基化时间、甲基化温度、酸性甲醇体积、酸性甲醇组成对甲基化效率的影响。本研究表明，酸性甲醇甲基化效率可以通过增加酸性甲醇的体积、甲基化温度、甲基化时间或三者来提高。作者还研究了与酸性甲醇甲基化相关的其他常见分析问题。建议进行额外的研究以进一步优化用于HAA分析的酸性甲醇甲基化程序。
Acidic methanol methylation is a common derivatization process for haloacetic acid (HAA) analysis. The Pennsylvania State University at Harrisburg and EPCOR Water Services in Edmonton, Alta., conducted a study on acidic methanol methylation for HAAs. Using the current methylation conditions (US Environmental Protection Agency method 552.2), the authors observed incomplete methylation of HAAs, especially for trihaloacetic acids, which could significantly affect the accuracy of these HAA analytical results. The effects of methylation time, methylation temperature, volume of acidic methanol, and composition of acidic methanol on methylation efficiency were studied. This research suggests that acidic methanol methylation efficiency could be improved by increasing the volume of acidic methanol, methylation temperature, methylation time, or all three. The authors also investigated other common analytical problems associated with acidic methanol methylation. Additional studies are suggested to further optimize the acidic methanol methylation procedure for HAA analysis.