Long-term follow-up after BCNU wafer implantation in patients with newly diagnosed glioblastoma
Long-term follow-up after BCNU wafer implantation in patients with newly diagnosed glioblastoma
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新诊断胶质母细胞瘤患者 BCNU 晶片植入后的长期随访
DOI：
10.1016/j.jocn.2021.01.037
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kumabe T.
中科院分区：
文献类型：
--
作者：
Shibahara I;Miyasaka K;Sekiguchi A;Ishiyama H;Inukai M;Yasui Y;Watanabe T;Sato S;Hide T;Kumabe T.
1,3-双（2-氯乙基）-1-亚硝基脲（BCNU，或Carmustine）晶片是术中植入式晶片，用于实现局部肿瘤控制。在植入病例的长期随访中，关于晶片行为的数据很少。我们回顾了64例新诊断的胶质母细胞瘤患者的数据，这些患者分别接受手术、BCNU片、放射治疗和替莫唑胺治疗。该队列包括55例首次复发的患者，其中49例肿瘤进展至死亡。通过对每例晚期患者的磁共振成像和尸检病例的分析，阐明了植入硅片后肿瘤的发展模式。我们根据磁共振成像将首次复发类型细分为局部、远处和多灶，或根据辐射场将其细分为内野、外野和边缘。第一种复发类型为局部复发33例（60%），远处复发13例（24%），多灶复发9例（16%），内野38例（69%），外野13例（24%），边缘4例（7%）。终末期磁共振成像与死亡之间的中位时间间隔和平均时间间隔分别为2.0和2.3个月。值得注意的是，13例首次远处复发的患者即使在终末期也没有明显的局部肿瘤放射学进展。BCNU晶片植入术后的长期随访显示，首次远处复发患者的局部肿瘤得到长期控制，直至终末期。
1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU, or Carmustine) wafers are intraoperatively implantable wafers used to achieve local tumor control. There is scarce data about the behavior of wafers in the long-term follow-up of implanted cases. We reviewed the data of 64 patients with newly diagnosed glioblastoma treated by surgery, BCNU wafers, radiation therapy, and temozolomide administration. This cohort included 55 patients who presented first recurrence, and 49 of them showed tumor progression to death. The MR imaging of each patient at the terminal stage and an autopsy case were used to elucidate the tumor progression pattern after the wafer implantation. We subdivided the first recurrence pattern into local, distant, and multifocal based on MR imaging or into infield, outfield, and marginal based on the radiation field. The first recurrence pattern was 33 patients (60%) with local, 13 (24%) with distant, and nine (16%) with multifocal recurrence, or 38 patients (69%) with infield, 13 (24%) with outfield, and four (7%) with marginal. The median and mean time intervals between MR imaging at the terminal stage and death were 2.0 and 2.3 months, respectively. Of note, 13 patients with first distant recurrence had no obvious radiological local tumor progression even at the terminal stage. Long-term follow-up after BCNU wafer implantation revealed that patients with first distant recurrence had long-lasting local tumor control until the terminal stage.
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影响因子：
3.3
作者：
Sonoda, Yukihiko;Yokosawa, Michiko;Tominaga, Teiji
通讯作者：
Tominaga, Teiji
影响因子：
4.1
作者：
Chaichana KL;Zadnik P;Weingart JD;Olivi A;Gallia GL;Blakeley J;Lim M;Brem H;Quiñones-Hinojosa A
通讯作者：
Quiñones-Hinojosa A
影响因子：
5.6
作者：
Burger MC;Breuer S;Cieplik HC;Harter PN;Franz K;Bähr O;Steinbach JP
通讯作者：
Steinbach JP
BCNU 晶圆植入切除恶性胶质瘤后的复发模式：单一机构的回顾性审查。
影响因子：
2
作者：
S. Shimato;T. Nishizawa;Tomotaka Ohshima;Tasuku Imai;Shunsaku Goto;Taiki Yamamoto;Kyozo Kato
通讯作者：
Kyozo Kato
影响因子：
168.9
作者：
Herrlinger, Ulrich;Tzaridis, Theophilos;Glas, Martin
通讯作者：
Glas, Martin