Targeting Cancer Stem Cells: Promises and Challenges
Targeting Cancer Stem Cells: Promises and Challenges
复制标题
DOI：
10.2174/1871520615666150716104152
复制
发表时间：
2016-01-01
影响因子：
2.8
通讯作者：
Dubrovska, Anna
中科院分区：
文献类型：
--
作者：
Kuhlmann, Jan Dominik;Kurth, Linda Hein Ina;Dubrovska, Anna
最近的发现提供了令人信服的证据，即每个肿瘤中的干细胞群体是治疗失败的关键因素，无论这些群体是短暂的还是稳定的。因此，越来越清楚的是，有效的肿瘤治疗需要根除整个CSC群体。CSC在肿瘤发生和复发中的潜在作用促使了对CSC特异性治疗的研究。然而，CSC特征的高度多样性和可塑性可能会挑战靶向CSC的治疗策略的发展。此外，考虑到CSC的起源仍然存在争议，并且越来越多的实验证据表明肿瘤细胞重编程的可能性，有效的抗癌治疗应该根除CSC和肿瘤块以及防止肿瘤去分化。在这篇文章中，我们讨论了肿瘤发展的干细胞概念的新见解，回顾了在临床前和临床研究中评估的根除CSC的治疗策略，并总结了确定新的CSC靶向治疗的策略。
Recent discoveries have provided the compelling evidence that stem cell populations within each individual tumor are key contributors of therapy failure regardless of whether these populations are transient or stable. Thus, it is becoming increasingly clear that efficient tumor treatment requires eradication of the entire CSC population. The potential role of CSCs in tumor initiation and relapse has motivated an investigation of the CSC-specific treatments. However, development of the therapeutic strategies targeting CSCs might be challenged by a high diversity and plasticity of CSC features. Moreover, taking in account that an origin of CSC remains controversial and accumulating experimental evidence suggests a possibility of tumor cell reprogramming, efficient anti-cancer treatment should eradicate both CSCs and tumor bulk as well as prevent tumor dedifferentiation. In this article we discuss new insights into the stem cell concept of tumor development, review the treatment strategies eradicating CSCs that have been evaluated in preclinical and clinical studies and summarize the strategies to identify new CSC-targeted therapy.