Investigation of a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population: A Family-Based Study.
Investigation of a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population: A Family-Based Study.
复制标题
组氨酸脱羧酶基因在中国汉族人群抽动秽语综合征中可能作用的调查：一项基于家族的研究
DOI：
10.1371/journal.pone.0160265
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Liu S
中科院分区：
文献类型：
--
作者：
Dong H;Liu W;Liu M;Xu L;Li Q;Zhang R;Zhang X;Liu S
多发性抽动症(TS)是一种多基因神经精神疾病。先前的研究表明，组胺能系统的失调可能在疾病的发生中起着至关重要的作用。在这项研究中，我们研究了组氨酸脱羧酶基因(HDC)在中国汉族人群TS易感性中的作用。在对241个TS核心家系进行基因分型后，我们利用传递不平衡检验(TDT)和单倍型相对危险度(HRR)分析了3个标签HDC单核苷酸多态(rs854150、rs854151和rs854157)。Rs854150：χ2=0.472，P=0.537，OR=1.097，95%CI=0.738~1.630；rs854151：χ2=0.043，P=0.889，OR=1.145，95%CI=0.767~1.709；rs854157：χ2=0.984，P=0.367，OR=1.020，95%CI=0.508~2.049。Rs854150：χ2=0.211，P=0.646，OR=1.088，95%CI=0.759~1.559；rs854151：χ2=0.134，P=0.714，OR=0.935，95%CI=0.653~1.339；rs854157：χ2=0.841，P=0.359，OR=1.206，95%CI=0.808~1.799。此外，基于单倍型的单倍型相对风险显示负相关。尽管这些发现表明在中国汉族人群中HDC和TS之间不太可能存在关联，但不能排除HDC在TS病因学中的潜在作用。未来的研究应该使用不同的人群和更大的样本来更彻底地研究这一点。
Tourette syndrome (TS) is a polygenic neuropsychiatric disease. Previous studies have indicated that dysregulation in the histaminergic system may play a crucial role in disease onset. In this study, we investigated the role of the histidine decarboxylase gene (HDC) in TS susceptibility in the Chinese Han population. After genotyping 241 TS nuclear families trios, we analyzed three tag HDC single nucleotide polymorphisms (rs854150, rs854151, and rs854157) in a family-based study using the transmission disequilibrium test (TDT) and haplotype relative risk (HRR). TDT showed no over-transmission in these SNPs across the HDC region (for rs854150: χ2 = 0.472, P = 0.537, OR = 1.097, 95%CI = 0.738–1.630; for rs854151: χ2 = 0.043, P = 0.889, OR = 1.145, 95%CI = 0.767–1.709; for rs854157:χ2 = 0.984, P = 0.367, OR = 1.020, 95%CI = 0.508–2.049). HRR also showed the same tendency (for rs854150: χ2 = 0.211, P = 0.646, OR = 1.088, 95%CI = 0.759–1.559; for rs854151: χ2 = 0.134, P = 0.714, OR = 0.935, 95%CI = 0.653–1.339; for rs854157:χ2 = 0.841, P = 0.359, OR = 1.206, 95%CI = 0.808–1.799). Additionally, the haplotype-based haplotype relative risk showed a negative association. Although these findings indicate an unlikely association between HDC and TS in the Chinese Han population, a potential role for HDC cannot be ruled out in TS etiology. Future research should investigate this more thoroughly using different populations and larger samples.