Fractalkine in the peritoneal fluid of women with endometriosis
Fractalkine in the peritoneal fluid of women with endometriosis
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DOI：
10.1016/j.ijgo.2005.06.018
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发表时间：
2005-10
影响因子：
3.8
通讯作者：
K. Shimoya;Q. Zhang;K. Temma-Asano;S. Hayashi;T. Kimura;Y. Murata
中科院分区：
文献类型：
--
作者：
K. Shimoya;Q. Zhang;K. Temma-Asano;S. Hayashi;T. Kimura;Y. Murata
目的：探讨腹水中Fractalkine的存在及其与子宫内膜异位症的关系。方法：腹腔液及外周血标本均取自因不孕症或经腹腔镜行膀胱切除术的患者。三份腹膜标本取自子宫切除术患者。结果：腹水中检测到Fractalkine蛋白。腹膜表面细胞和腹膜血管周围细胞呈阳性染色。腹腔液中有CX3CR1阳性细胞。子宫内膜异位症患者腹水中Fractalkine浓度低于非子宫内膜异位症患者。结论：子宫内膜异位症患者腹腔液中Fractalkine水平降低可能参与了子宫内膜异位症的发病机制。
Objective:The objective of this study was to evaluate the presence of fractalkine in the ascites and the association between fractalkine levels in the ascites and endometriosis.Methods:Peritoneal fluids and peripheral blood samples were obtained from patients undergoing laparoscopy for infertility work‐up or laparoscopic cystectomy. Three samples of peritoneum were obtained from patients undergoing hysterectomy. Western blotting, RT‐PCR and immunohistochemistry were performed.Results:Fractalkine protein was detected in the ascites. Positive staining was confirmed in peritoneal surface cells and perivascular cells of the peritoneum. CX3CR1 positive cells were present in the cells in the peritoneal fluid. The fractalkine concentrations in the ascites of patients with endometriosis were lower than those without endometriosis. There was no significant difference between serum fractalkine levels in patients with and without endometriosis.Conclusion:The decreased level of fractalkine found in the peritoneal fluid of patients with endometriosis may contribute to the pathogenesis of endometriosis.