Foveal thickness in occult macular dystrophy.
Foveal thickness in occult macular dystrophy.
复制标题
隐匿性黄斑营养不良的中心凹厚度。
DOI：
10.1016/s0002-9394(02)02158-x
复制
发表时间：
2003
影响因子：
4.2
通讯作者：
Y. Miyake
中科院分区：
文献类型：
--
作者：
M. Kondo;Yasuki Ito;S. Ueno;C. Piao;H. Terasaki;Y. Miyake
隐匿性黄斑营养不良（OMD）是一种遗传性黄斑营养不良，其特征是进行性黄斑功能障碍，无任何可见的眼底异常。我们使用光学相干断层扫描（OCT）研究了OMD患者的中心凹厚度。OCT图像测量的中心凹厚度：11例（22只眼）OMD患者的中心凹厚度与20例（27只眼）年龄匹配的正常对照者的中心凹厚度进行比较，结果患者组中心凹厚度（96.5 ± 19.5 μm）显著小于正常对照组（133.3 ± 9.0 μm，P <0.0001，Mann-Whitney U检验）。22只OMD眼中有18只眼的中心凹厚度小于正常范围下限。中心凹厚度与视力、年龄或发病时间之间无统计学显著相关性。结论：OMD患者黄斑区存在明显的解剖学改变。
PURPOSEOccult macular dystrophy (OMD) is an inherited macular dystrophy characterized by a progressive macular dysfunction without any visible fundus abnormality. We studied the foveal thickness in patients with OMD using optical coherence tomography (OCT).DESIGNObservational case series. Foveal thickness by OCT images.METHODSFoveal thickness obtained from 22 eyes of 11 patients with OMD was compared with that from 27 eyes of 20 age-matched normal controls.RESULTSMean foveal thickness in the patients group (96.5 ± 19.5 μm) was significantly thinner than that in the normal controls (133.3 ± 9.0 μm, P < .0001, Mann–Whitney U test). Eighteen of 22 eyes with OMD had foveal thickness that were thinner than the lower limit of the normal range. There was no statistically significant correlation between the foveal thickness and visual acuity, age, or duration from onset. CONCULUSION: These results demonstrated that there are significant anatomic changes in the macula of patients with OMD.