Monoamine metabolites in CSF and suicidal behavior.
Monoamine metabolites in CSF and suicidal behavior.
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脑脊液中的单胺代谢物与自杀行为。
DOI：
10.1001/archpsyc.1981.01780310031002
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发表时间：
1981
影响因子：
--
通讯作者：
Lars Sjüstrand
中科院分区：
文献类型：
--
作者：
L. Träskman;M. Åsberg;L. Bertilsson;Lars Sjüstrand
测定了30例自杀未遂患者和45例健康志愿者脑脊液中单胺类代谢产物5-羟基吲哚乙酸(5-HIAA)、高香草酸(HVA)和3-甲氧基-4-羟基苯甘醇(MHPG)的浓度。自杀未遂者的脑脊液5-HIAA水平明显低于对照组，尤其是那些有更多暴力企图的人。在调整了对照组和患者之间的身高和年龄差异后，5-HIAA水平的差异变得更加明显。在腰椎穿刺术时未被诊断为抑郁症的自杀患者中，5-HIAA浓度也低于正常水平，而HVA水平仅在抑郁症患者中降低。对这些患者和另外89名患者(抑郁和/或自杀)的跟踪研究发现，在脑脊液HIAA水平低于中位数的患者腰椎穿刺术后一年内，自杀死亡率为20%。
Cerebrospinal fluid concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenyl glycol (MHPG) were measured in 30 psychiatric patients who had attempted suicide and 45 healthy volunteers. The suicide attempters had a significantly lower CSF 5-HIAA level than the controls, especially those who had made more violent attempts. After adjustment for differences in body height and age between controls and patients, the difference in 5-HIAA level became even more marked. Concentrations of 5-HIAA also were lower than normal in suicidal patients who were not diagnosed as depressed at the time of lumbar puncture, while HVA levels were lowered only in the depressives. A follow-up study of these and 89 more patients (depressed and/or suicidal) revealed a 20% mortality by suicide within a year after lumbar puncture in patients with a CSF-HIAA level below the median.