Thalamic amnesia after infarct: The role of the mammillothalamic tract and mediodorsal nucleus.
Thalamic amnesia after infarct: The role of the mammillothalamic tract and mediodorsal nucleus.
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梗塞后的丘脑性健忘症：乳腺丘脑和中型核的作用。
DOI：
10.1212/wnl.0000000000002226
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发表时间：
2015-12-15
期刊：
影响因子：
9.9
通讯作者：
Pariente J
中科院分区：
文献类型：
--
作者：
Danet L;Barbeau EJ;Eustache P;Planton M;Raposo N;Sibon I;Albucher JF;Bonneville F;Peran P;Pariente J
提高目前对丘脑遗忘症背后机制的理解，因为尚不清楚它是否与特定核团（特别是前核或背内侧核）的损伤直接相关，或与乳头丘脑束（MTT）病变间接相关。我们招募了12名左丘脑梗死患者和25名健康匹配对照。所有人都接受了语言和视觉记忆、执行功能、语言和情感的全面神经心理学评估，以及高分辨率结构体积MRI扫描。丘脑病变手动分割和自动定位与计算机丘脑图谱。除了将患者与对照组进行比较外，我们还将患者分为MTT完整或受损的亚组。仅1例患者的前核有一个小的病变。大多数病变包括背内侧核（n = 11）和板内核（n = 12）。患者在言语记忆任务上的表现比对照组差，但5例MTT完整的患者表现出孤立的内侧背核（MD）病变，仅表现出中度记忆障碍。7例MTT受损的患者在言语记忆任务中的表现比MTT完好的患者差。MTT和MD中的病变导致记忆障碍，在MTT的情况下严重，在MD的情况下程度较轻，从而突出了这2种结构在记忆电路中所起的作用。
To improve current understanding of the mechanisms behind thalamic amnesia, as it is unclear whether it is directly related to damage to specific nuclei, in particular to the anterior or mediodorsal nuclei, or indirectly related to lesions of the mammillothalamic tract (MTT). We recruited 12 patients with a left thalamic infarction and 25 healthy matched controls. All underwent a comprehensive neuropsychological assessment of verbal and visual memory, executive functions, language, and affect, and a high-resolution structural volumetric MRI scan. Thalamic lesions were manually segmented and automatically localized with a computerized thalamic atlas. As well as comparing patients with controls, we divided patients into subgroups with intact or damaged MTT. Only one patient had a small lesion of the anterior nucleus. Most of the lesions included the mediodorsal (n = 11) and intralaminar nuclei (n = 12). Patients performed worse than controls on the verbal memory tasks, but the 5 patients with intact MTT who showed isolated lesions of the mediodorsal nucleus (MD) only displayed moderate memory impairment. The 7 patients with a damaged MTT performed worse on the verbal memory tasks than those whose MTT was intact. Lesions in the MTT and in the MD result in memory impairment, severely in the case of MTT and to a lesser extent in the case of MD, thus highlighting the roles played by these 2 structures in memory circuits.