HDL (High-Density Lipoprotein) Cholesterol Efflux Capacity Is Associated With Incident Cardiovascular Disease in the General Population A Case-Control Study From the PREVEND Cohort
HDL (High-Density Lipoprotein) Cholesterol Efflux Capacity Is Associated With Incident Cardiovascular Disease in the General Population A Case-Control Study From the PREVEND Cohort
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DOI：
10.1161/atvbaha.119.312645
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发表时间：
2019-09-01
影响因子：
8.7
通讯作者：
Tietge, Uwe J. F.
中科院分区：
文献类型：
--
作者：
Ebtehaj, Sanam;Gruppen, Eke G.;Tietge, Uwe J. F.
目的：重点正在从HDL-C（高密度脂蛋白胆固醇）作为心血管疾病（CVD）的预测生物标志物转向抗动脉粥样硬化HDL功能。然而，关于HDL功能指标与CVD事件的前瞻性关联的数据有限。目前的工作旨在确定基线HDL-C外排能力（CEC）是否与普通人群中未来的CVD事件相关。方法和结果：我们在PREVEND（肾脏和血管终末期疾病预防）队列的参与者中进行了一项前瞻性研究（随访，12年）。从总体n=8592例受试者中排除了325例既往有CVD事件的受试者;在剩余的8267例合格受试者中，选择随访期间新发CVD事件的所有受试者，并在年龄、性别、吸烟状况和HDL-C水平方面与对照组进行个体匹配。使用人THP-1衍生的巨噬细胞泡沫细胞和载脂蛋白B去除的血浆定量基线CEC。尽管病例（n=351）和对照（n= 354）之间的HDL-C和apoA（载脂蛋白）-I水平相同，但病例的CEC显着较低（0.93 +/- 0.29 vs 1.01 +/- 0.24任意单位; P
Objective: Focus is shifting from HDL-C (high-density lipoprotein cholesterol) as predictive biomarker for cardiovascular disease (CVD) towards antiatherogenic HDL functionalities. Still, limited data exist on the prospective association of HDL function metrics with CVD events. The current work aimed to determine, if baseline HDL-C efflux capacity (CEC) is associated with future CVD events in the general population. Approach and Results: We performed a prospective study among participants of the PREVEND (Prevention of Renal and Vascular End-stage Disease) cohort (follow-up, 12 years). From the overall n=8592 subjects 325 with previous CVD events were excluded; of the remaining 8267 eligible participants all subjects with new CVD events during follow-up were selected and individually matched to controls for age, sex, smoking status, and HDL-C levels. CEC at baseline was quantified using human THP-1-derived macrophage foam cells and apolipoprotein B-depleted plasma. Despite identical HDL-C and apoA (apolipoprotein)-I levels between cases (n=351) and controls (n=354) CEC was significantly lower in cases (0.93 +/- 0.29 versus 1.01 +/- 0.24 arbitrary units; P