Smoking cessation and acute airway response to ozone.
Smoking cessation and acute airway response to ozone.
复制标题
戒烟和对臭氧的急性气道反应。
DOI：
10.1080/00039896.1991.9934389
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Foster,WM
中科院分区：
文献类型：
--
作者：
Emmons,K;Foster,WM
在室内暴露于臭氧或过滤空气期间，测量无症状吸烟者的肺功能和症状反应。受试者在习惯吸烟时和戒烟6个月后进行评估。治疗开始时，有33.4±15.6包/年吸烟史且肺功能基本正常的受试者(n=18)对臭氧暴露(0.4ppm持续2 h)无反应。一组匹配的对照组吸烟者(n=16)对过滤的空气暴露没有反应。戒烟6个月后，基础MMF率显著提高(P<；0.02)；戒烟者(n=15)将这一指数从3.32提高到4.11 L/S。戒烟6个月和再次暴露于0.4ppm臭氧的9名受试者均有显著差异(P<；；MMF下降(从3.86±1.32[标准差]降至2.99±0.94 L/S，即下降22.5%)，舒适性略有下降，干咳发生率增加(p<；.10)。在臭氧暴露期间，FVC没有降低。对照组吸烟者(n=6)对过滤后的空气暴露无反应。戒烟者对臭氧的反应与他们在戒烟期间改善的MMF相关(系数=0.88)，即戒烟后MMF基线增加最大的受试者在臭氧暴露期间MMF急剧下降最大。本研究提示，无症状吸烟者对臭氧的功能反应和症状敏感性减弱或消失；戒烟6个月后，肺功能改善，出现对臭氧的呼吸道反应和主观意识。然而，作为非吸烟者对臭氧暴露的常见反应，FVC的减少并不能通过戒烟6个月而恢复。
Pulmonary function and symptom responses of asymptomatic smokers were measured during chamber exposures to ozone or filtered air. Subjects were evaluated while habituated to smoking and after 6 mo of smoking abstinence. At the onset of treatment, subjects (n= 18) who had a history of smoking 33.4 ± 15.6 packs/y and who had almost normal pulmonary function (forced vital capacity [FVC], forced expiratory volume in 1 s [FEV1.0], and mid-maximal flow [MMF] were g 82% of predicted) were unresponsive to ozone exposure (0.4 ppm for 2 h). A matched group of control smokers (n= 16) did not respond to filtered air exposure. After 6 mo of smoking cessation, baseline MMF rates improved significantly (p< .02); exsmokers (n= 15) raised this index from 3.32 to 4.11 l/s. All 9 subjects who abstained from smoking cigarettes for 6 mo and who were re-exposed to 0.4 ppm ozone had significant (p< .01) reductions in MMF (from a mean of 3.86 ± 1.32 [standard deviation] to 2.99 ± 0.94 l/s, i.e., 22.5% reduction) and marginally significant reductions in comfort, as evidenced by an increase in the incidence of dry cough (p< .10). The FVC was not reduced during ozone exposure. Control exsmokers (n= 6) remained unresponsive to filtered air exposure. The exsmokers' responses to ozone and their improved MMF during the period of smoking abstinence were correlated (coefficient = .88), i.e., subjects with the largest baseline gains in MMF after withdrawal experienced the largest acute decrements in MMF during ozone exposure. This study suggests that functional response and symptom sensitivity to ozone are moderated or nonexistent in asymptomatic smokers; after 6 mo of smoking cessation and improvement in lung function, airway response and subjective awareness to ozone emerge. However, the reduction in FVC, which is a common response of nonsmokers to ozone exposure, was not restored by 6 mo of abstaining from smoking.