UNCOUPLING OF OXIDATIVE-PHOSPHORYLATION
UNCOUPLING OF OXIDATIVE-PHOSPHORYLATION
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DOI：
10.1016/0304-4173(76)90010-0
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发表时间：
1976-01-01
期刊：
影响因子：
--
通讯作者：
HANSTEIN, WG
中科院分区：
文献类型：
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作者：
HANSTEIN, WG
解偶联剂是一大类相对简单的有机化学品，具有消除底物氧化与ATP合成偶联的能力。本文综述了氧化磷酸化解偶联的以下几个方面：磷酸化效率;呼吸控制;解偶联的类型;解偶联剂与其他抑制剂的相互作用;解偶联剂与线粒体膜和膜组分的相互作用;解偶联剂对线粒体的亲和标记;化学计量学的概念;苦味酸的解偶联以及氧化磷酸化解偶联的机制。
Uncouplers, a large class of relatively simple organic chemicals, have the ability to abolish the coupling of substrate oxidation to ATP synthesis. This review (100 references) covers the following aspects of uncoupling of oxidative phosphorylation: phosphorylation efficiency; respiratory control; types of uncoupling; interactions of uncouplers with other inhibitors; interactions of uncouplers with the mitochondrial membrane and membrane components; affinity labeling of mitochondria by uncouplers; the concept of stoichiometry; uncoupling of picrate and the mechanism of uncoupling of oxidative phosphorylation.