Dietary saturated fat intake is inversely associated with bone density in humans: Analysis of NHANES III
Dietary saturated fat intake is inversely associated with bone density in humans: Analysis of NHANES III
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DOI：
10.1093/jn/136.1.159
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发表时间：
2006-01-01
影响因子：
4.2
通讯作者：
Graubard, BI
中科院分区：
文献类型：
--
作者：
Corwin, RL;Hartman, TJ;Graubard, BI
越来越多的证据表明，饮食中脂肪的数量和类型对骨骼健康有重要影响。这些证据大多来自动物研究。在已经进行的为数不多的人体研究中，受试者和/或主要是女性受试者的数量相对较少。本研究使用NHANES III数据(n=14,850)评估了饮食脂肪与男性和女性髋部骨密度(BMD)的关系。使用SAS可调用SUDAAN的多变量模型来调整抽样方案。根据年龄、性别、体重、身高、种族、总能量和钙摄入量、吸烟和负重锻炼对模特进行了调整。对来自女性的数据进行了进一步调整，以使用激素替代疗法。在模型中包括饮食蛋白质、维生素C和β-胡萝卜素并不影响结果。4个性别/年龄组的平均BMD由总脂肪摄入量和饱和脂肪摄入量的五分之一进行协方差分析。饱和脂肪摄入量与髋部几个部位的骨密度呈负相关。50岁男性的影响最大(股骨颈呈线性趋势，P=0.004)。对于股骨颈，与饱和脂肪摄入量最低五分之一的男性相比，调整后的平均骨密度低4.3%(骨密度，95%CI：最高五分之一：0.922 g/cm(2)，0.909-0.935；最低五分之一：0.963 g/cm(2)，95%CI：0.950-0.976)。这些数据表明，BMD与饱和脂肪摄入量呈负相关，男性可能特别容易受到这些影响的影响。
Mounting evidence indicates that the amount and type of fat in the diet can have important effects on bone health. Most of this evidence is derived from animal studies. Of the few human studies that have been conducted, relatively small numbers of subjects and/or primarily female subjects were included. The present study assessed the relation of dietary fat to hip bone mineral density (BMD) in men and women using NHANES III data (n = 14,850). Multivariate models using SAS-callable SUDAAN were used to adjust for the sampling scheme. Models were adjusted for age, sex, weight, height, race, total energy and calcium intakes, smoking, and weight-bearing exercise. Data from women were further adjusted for use of hormone replacement therapy. Including dietary protein, vitamin C, and beta-carotene in the model did not influence the outcome. Analysis of covariance was used to generate mean BMD by quintile of total and saturated fat intake for 4 sex/age groups. Saturated fat intake was negatively associated with BMD at several hip sites. The greatest effects were seen among men < 50 y old (linear trend P = 0.004 for the femoral neck). For the femoral neck, adjusted mean BMD was 4.3% less among men with the highest compared with the lowest quintile of saturated fat intake (BMD, 95% Cl: highest quintile: 0.922 g/cm(2), 0.909-0.935; lowest quintile: 0.963 g/cm(2), 95% Cl: 0.950-0.976). These data indicate that BMD is negatively associated with saturated fat intake, and that men may be particularly vulnerable to these effects.