Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep.
Transcranial Electrical Stimulation targeting limbic cortex increases the duration of human deep sleep.
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DOI：
10.1016/j.sleep.2021.03.001
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发表时间：
2021-05
期刊：
影响因子：
4.8
通讯作者：
Tucker DM
中科院分区：
文献类型：
--
作者：
Hathaway E;Morgan K;Carson M;Shusterman R;Fernandez-Corazza M;Luu P;Tucker DM
研究人员提出，睡眠受损可能是从轻度认知障碍（MCI）发展到阿尔茨海默病（AD）的因果关系。最近的几项研究结果表明，加强深度睡眠（N3）可以改善MCI患者的神经健康，并缓冲AD的风险。具体来说，额叶脑区的经颅电刺激（TES），N3睡眠的慢振荡（SO）的推断来源，可以延长N3睡眠持续时间，并改善最近学习的信息的陈述性记忆。我们实验室最近使用密集阵列脑电图（dEEG）的工作将SO的来源定位于前缘部位-这表明用TES靶向这些部位可能更有效地增强N3。在本研究中，我们招募了13名健康成年人（M = 42岁）参与三个通宵睡眠EEG记录，他们接受低水平（0.5 mA）TES，旨在针对前边缘区和假刺激（安慰剂）。我们使用卷积神经网络，在专业评分的EEG睡眠阶段上进行训练和测试，以预测每个记录的睡眠阶段。与假手术组相比，边缘靶向TES显著增加了N3睡眠的持续时间。与假手术相比，TES还显著增加了左颞顶和左枕部头皮区域中0.5-1 Hz频带（相对于TES前时期）的频谱功率。这些结果表明，即使是低水平的TES，当专门针对前缘部位时，也可以增加深度（N3）睡眠，从而有助于健康的睡眠质量。
Researchers have proposed that impaired sleep may be a causal link in the progression from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD). Several recent findings suggest that enhancing deep sleep (N3) may improve neurological health in persons with MCI, and buffer the risk for AD. Specifically, Transcranial Electrical Stimulation (TES) of frontal brain areas, the inferred source of the Slow Oscillations (SOs) of N3 sleep, can extend N3 sleep duration and improve declarative memory for recently learned information. Recent work in our laboratory using dense array Electroencephalography (dEEG) localized the sources of SOs to anterior limbic sites – suggesting that targeting these sites with TES may be more effective for enhancing N3. For the present study, we recruited 13 healthy adults (M = 42 years) to participate in three all-night sleep EEG recordings where they received low level (0.5 mA) TES designed to target anterior limbic areas and a sham stimulation (placebo). We used a convolutional neural network, trained and tested on professionally scored EEG sleep staging, to predict sleep stages for each recording. When compared to the sham session, limbic-targeted TES significantly increased the duration of N3 sleep. TES also significantly increased spectral power in the 0.5–1 Hz frequency band (relative to pre-TES epochs) in left temporoparietal and left occipital scalp regions compared to sham. These results suggest that even low-level TES, when specifically targeting anterior limbic sites, can increase deep (N3) sleep and thereby contribute to healthy sleep quality.