Tight junction pore and leak pathways: a dynamic duo.
Tight junction pore and leak pathways: a dynamic duo.
复制标题
紧密的连接孔和泄漏途径：一个动态的二人组。
DOI：
10.1146/annurev-physiol-012110-142150
复制
发表时间：
2011
影响因子：
18.2
通讯作者：
Turner JR
中科院分区：
文献类型：
--
作者：
Shen L;Weber CR;Raleigh DR;Yu D;Turner JR
限制液体、离子和较大溶质通过的组织屏障对于多细胞生物的发育至关重要。在简单的生物体中，这允许不同的细胞类型与外部环境相互作用。在更复杂的物种中，能够形成屏障的细胞类型的多样性急剧增加。尽管这些形成屏障的细胞的质膜阻止了大多数亲水性溶质的流动，但细胞间的旁路或分流通路也必须被密封。脊椎动物的这一功能是通过闭锁带或紧密连接来完成的。紧密连接屏障不是绝对的，而是选择性渗透的，并且能够根据大小和电荷区分溶质。在过去的 20 年里，许多紧密连接成分已被识别，最近的进展为调节结构和功能的蛋白质和相互作用提供了新的见解。这篇综述在历史背景下呈现了这些数据，并提出了一个综合模型，其中紧密连接蛋白相互作用的动态调节决定了屏障功能。
Tissue barriers that restrict passage of liquids, ions, and larger solutes are essential for the development of multicellular organisms. In simple organisms this allows distinct cell types to interface with the external environment. In more complex species, the diversity of cell types capable of forming barriers increases dramatically. Although the plasma membranes of these barrier-forming cells prevent flux of most hydrophilic solutes, the paracellular, or shunt, pathway between cells must also be sealed. This function is accomplished in vertebrates by the zonula occludens, or tight junction. The tight junction barrier is not absolute but is selectively permeable and is able to discriminate between solutes on the basis of size and charge. Many tight junction components have been identified over the past 20 years, and recent progress has provided new insights into the proteins and interactions that regulate structure and function. This review presents these data in a historical context and proposes an integrated model in which dynamic regulation of tight junction protein interactions determines barrier function.