Cdc42: An important regulator of neuronal morphology
Cdc42: An important regulator of neuronal morphology
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DOI：
10.1016/j.biocel.2011.11.022
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发表时间：
2012-03-01
影响因子：
4
通讯作者：
Ponimaskin, Evgeni
中科院分区：
文献类型：
--
作者：
Chen, Chen;Wirth, Alexander;Ponimaskin, Evgeni
神经元形态和活性依赖性突触修饰的调节涉及肌动蛋白细胞骨架的重组。在许多细胞类型中，肌动蛋白细胞骨架的动态变化由Rho家族的小GTP酶如RhoA控制。Rac1和Cdc42。作为肌动蛋白和微管细胞骨架的关键调节因子，Rho GTP酶也已成为树突和棘结构可塑性的重要调节因子。多项研究表明，Rac1和Cdc42是促进神经突生长和生长锥突出的正调控因子，而RhoA的激活诱导应力纤维形成，导致生长锥塌陷和神经突收缩。本文综述了Cdc42在神经系统中生理和病理功能的分子机制。我们还讨论了应用不同的FRET为基础的生物传感器作为一个强大的方法来检查在活细胞中的Cdc42活性的动态。(C)2011爱思唯尔有限公司保留所有权利。
Regulation of neuronal morphology and activity-dependent synaptic modifications involves reorganization of the actin cytoskeleton. Dynamic changes of the actin cytoskeleton in many cell types are controlled by small GTPases of the Rho family, such as RhoA. Rac1 and Cdc42. As key regulators of both actin and microtubule cytoskeleton, Rho GTPases have also emerged as important regulators of dendrite and spine structural plasticity. Multiple studies suggest that Rac1 and Cdc42 are positive regulators promoting neurite outgrowth and growth cone protrusion, while the activation of RhoA induces stress fiber formation, leading to growth cone collapse and neurite retraction. This review focuses on recent advances in our understanding of the molecular mechanisms underlying physiological and pathological functions of Cdc42 in the nervous system. We also discuss application of different FRET-based biosensors as a powerful approach to examine the dynamics of Cdc42 activity in living cells. (C) 2011 Elsevier Ltd. All rights reserved.