Human cytomegalovirus vaccine development: Immune responses to look into vaccine strategy
Human cytomegalovirus vaccine development: Immune responses to look into vaccine strategy
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人类巨细胞病毒疫苗的开发：研究疫苗策略的免疫反应
DOI：
10.1080/21645515.2017.1391433
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发表时间：
2018-02
期刊：
影响因子：
--
通讯作者：
Wenxin Luo
中科院分区：
文献类型：
--
作者：
Lin Xia;Ruopeng Su;Zhiqiang An;Tongming Fu;Wenxin Luo
摘要人巨细胞病毒（HCMV）在高风险、免疫功能低下人群（包括实体器官移植受者和免疫系统尚未成熟的胎儿）中引起相当大的发病率和残疾。旨在改善疾病严重程度和预防HCMV感染的疫苗可分为两种主要的疫苗设计方法，一种侧重于病毒修饰，另一种侧重于单个抗原。然而，这两类候选人都没有成功地实现持久和保护性免疫。最近对自然免疫应答的研究为HCMV疫苗策略提供了新的见解。特别地，研究已经证明，五聚体复合物的掺入对于疫苗产生血清阳性个体中常见的有效中和抗体是必需的。本文综述了HCMV疫苗开发的最新研究结果，以及在提高对天然HCMV免疫力的认识的基础上设计疫苗时应考虑的关键因素。
ABSTRACT Human cytomegalovirus (HCMV) causes considerable morbidity and disability in high risk, immunocompromised populations including recipients of solid organ transplants, and fetuses whose immune systems are not yet mature. Vaccines aimed at ameliorating the severity of disease and preventing HCMV infection can be categorized into two main approaches of vaccine design, with one focusing on virus modification and the other on individual antigens. However, no candidates in either class have been successful in achieving durable and protective immunity. Recent studies on the natural immune response provide new insight into HCMV vaccine strategy. In particular, studies have demonstrated that the incorporation of a pentameric complex is necessary for a vaccine to generate the potent neutralizing antibodies often seen in seropositive individuals. This review summarizes recent findings in the development of HCMV vaccines and key considerations that should be taken into vaccine design based on improved understanding of natural HCMV immunity.
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影响因子：
5.5
作者：
Saccoccio, Frances M.;Sauer, Anne L.;Cui, Xiaohong;Armstrong, Amy E.;Habib, El-Sayed E.;Johnson, David C.;Ryckman, Brent J.;Klingelhutz, Aloysius J.;Adler, Stuart P.;McVoy, Michael A.
通讯作者：
McVoy, Michael A.
DOI：
10.1016/s0084-3954(09)79560-0
发表时间：
2011
期刊：
Yearbook of Pediatrics
影响因子：
--
作者：
J. Stockman
通讯作者：
J. Stockman
影响因子：
6.4
作者：
Wille PT;Wisner TW;Ryckman B;Johnson DC
通讯作者：
Johnson DC
DOI：
10.1126/science.1227919
发表时间：
2012-11-23
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Stern-Ginossar N;Weisburd B;Michalski A;Le VT;Hein MY;Huang SX;Ma M;Shen B;Qian SB;Hengel H;Mann M;Ingolia NT;Weissman JS
通讯作者：
Weissman JS
影响因子：
2.4
作者：
L. Stanberry
通讯作者：
L. Stanberry