Restoring aged stem cell functionality: Current progress and future directions
Restoring aged stem cell functionality: Current progress and future directions
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DOI：
10.1002/stem.3234
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发表时间：
2020-06-18
期刊：
影响因子：
5.2
通讯作者：
Beerman, Isabel
中科院分区：
文献类型：
--
作者：
Spehar, Kevin;Pan, Andrew;Beerman, Isabel
干细胞功能障碍是衰老的一个标志，与人类和其他哺乳动物的身体和认知能力下降有关[Cell2013;153:1194]。因此，它已成为衰老和干细胞领域的一个活跃研究领域，并且已采用各种技术来减轻体外和体内干细胞功能的衰退。虽然在模型生物体中开发的一些技术不能直接应用于人类，但其他技术有望在临床上延缓甚至减轻与衰老相关的负面表型。本综述重点关注饮食、治疗和小分子干预措施，这些干预措施提供了至少一种老年成体干细胞功能改善的证据。
Stem cell dysfunction is a hallmark of aging, associated with the decline of physical and cognitive abilities of humans and other mammals [Cell2013;153:1194]. Therefore, it has become an active area of research within the aging and stem cell fields, and various techniques have been employed to mitigate the decline of stem cell function both in vitro and in vivo. While some techniques developed in model organisms are not directly translatable to humans, others show promise in becoming clinically relevant to delay or even mitigate negative phenotypes associated with aging. This review focuses on diet, treatment, and small molecule interventions that provide evidence of functional improvement in at least one type of aged adult stem cell.