Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004.
Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004.
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DOI：
10.1097/qai.0b013e31828e604b
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发表时间：
2013-07-01
期刊：
影响因子：
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通讯作者：
CAPRISA 004 Trial Team
中科院分区：
文献类型：
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作者：
Naranbhai V;Samsunder N;Sandler NG;Roque A;Abdool Karim Q;Ndungʼu T;Carr WH;Altfeld M;Douek DC;Abdool Karim SS;CAPRISA 004 Trial Team
在CAPRISA004中，先天免疫激活是HIV感染风险女性中HIV感染的一个强有力的预测因子。确定激活的原因可以实现有针对性的预防干预。在这项研究中，脂多糖、可溶性CD14和肠道脂肪酸结合蛋白的血浆浓度在感染或未感染HIV的受试者之间没有差异，这些水平也与血浆细胞因子或自然杀伤细胞激活无关。在TLR2、4或7/8激动剂刺激下，hiv获得者和非获得者外周血单核细胞的趋化因子和细胞因子反应无差异。需要进一步的研究。
Innate immune activation was a strong predictor of HIV acquisition in women at risk for HIV in CAPRISA004. Identifying the cause/s of activation could enable targeted prevention interventions. In this study, plasma concentrations of lipopolysaccharide, soluble CD14 and intestinal fatty-acid binding protein did not differ between subjects who did or did not subsequently acquire HIV, nor were these levels correlated with plasma cytokines or natural killer cell activation. There was no difference between HIV-acquirers and non-acquirers in the chemokine and cytokine responses of peripheral blood mononuclear cells stimulated with TLR2, 4 or 7/8 agonists. Further studies are required.