Bone marrow ring sideroblasts in hematological diseases: an analysis of consecutive 1300 samples in a single institution
Bone marrow ring sideroblasts in hematological diseases: an analysis of consecutive 1300 samples in a single institution
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血液系统疾病中的骨髓环铁粒幼细胞：单个机构连续 1300 个样本的分析
DOI：
10.1007/s12185-021-03278-5
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发表时间：
2022
影响因子：
2.1
通讯作者：
Suzuki Takahiro
中科院分区：
文献类型：
--
作者：
Hayama Kei;Abe Yuka;Kamata Hirotoshi;Okina Sosei;Murakami Yaeko;Kanoh Yuhsaku;Suzuki Takahiro
日本MDS-RS的发病率已被公认为约5%，低于欧洲国家。在日本，铁染色测试的使用不足被认为是导致这种明显较低的患病率的一个可能因素。为了研究这一问题，我们分析了北里大学医院1300份血液病患者的骨髓标本中环状铁粒母细胞(RS)的比例，包括所有样本的铁染色。96例MDS患者中16例(16.7%)被诊断为MDS-RS，占MDS患者总数的26.2%。部分MDS-EB(22.9%)和AML-mRC(13.8%)患者也有 ≥ 15%的RS。而在无异型增生的髓系肿瘤和非髓系疾病中，仅有1例(2.2%)、2例(2.2%)、非髓系疾病的8例(0.8%)出现 ≥ 5%RS。这些结果表明，日本MDS-RS的患病率可能比传统认识的要高，而且RS主要局限于骨髓增生异常疾病。进一步的多中心研究将需要使用连续的骨髓样本和铁染色测试来证实我们的发现。
The incidence of MDS-RS in Japan has been recognized as about 5% which is lower than that in European countries. Insufficient use of iron staining tests in Japan has been noted as one conceivable factor contributing to this apparently lower prevalence. To investigate this issue, we analyzed the proportion of ring sideroblasts (RS) in 1300 bone marrow samples from patients with hematological diseases at Kitasato University Hospital, including iron staining of all samples. Sixteen of 96 patients with MDS (16.7%) were diagnosed with MDS-RS, and this accounted for 26.2% of MDS without excess blasts. Some MDS-EB (22.9%) and AML-MRC (13.8%) patients also had ≥ 15% RS. In contrast, RS were rarely found in myeloid neoplasms without dysplasia and non-myeloid diseases: only 1 in 46 (2.2%) patients with AML without dysplasia, 2 in 93 (2.2%) with MPN, and 8 in 984 (0.8%) with non-myeloid diseases had ≥ 5% RS. These results indicate that prevalence of MDS-RS in Japan may be higher than conventionally recognized and that RS are principally restricted to myelodysplastic disorders. Further multicenter studies using consecutive bone marrow samples with iron staining tests will be required to confirm our findings.
具有环状铁粒幼细胞的急性髓系白血病显示出跨继发性急性髓系白血病和新发急性髓系白血病的独特分子特征
影响因子：
10.1
作者：
P. Martin;S. Jeromin;K. Perglerová;C. Haferlach;W. Kern;T. Haferlach
通讯作者：
T. Haferlach
DOI：
10.1056/nejmoa1516192
发表时间：
2016-06-09
期刊：
The New England journal of medicine
影响因子：
--
作者：
Papaemmanuil E;Gerstung M;Bullinger L;Gaidzik VI;Paschka P;Roberts ND;Potter NE;Heuser M;Thol F;Bolli N;Gundem G;Van Loo P;Martincorena I;Ganly P;Mudie L;McLaren S;O'Meara S;Raine K;Jones DR;Teague JW;Butler AP;Greaves MF;Ganser A;Döhner K;Schlenk RF;Döhner H;Campbell PJ
通讯作者：
Campbell PJ
影响因子：
11.4
作者：
A. Matsuda;I. Jinnai;F. Yagasaki;S. Kusumoto;I. Murohashi;M. Bessho;K. Hirashima;S. Honda;M. Minamihisamatsu;K. Fuchigami;T. Matsuo;K. Kuriyama;M. Tomonaga
通讯作者：
M. Tomonaga