MATURATIONAL CHANGES IN CEREBRAL FUNCTION IN INFANTS DETERMINED BY F-18 DG POSITRON EMISSION TOMOGRAPHY
MATURATIONAL CHANGES IN CEREBRAL FUNCTION IN INFANTS DETERMINED BY F-18 DG POSITRON EMISSION TOMOGRAPHY
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DOI：
10.1126/science.3945811
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发表时间：
1986-02-21
期刊：
影响因子：
56.9
通讯作者：
PHELPS, ME
中科院分区：
文献类型：
--
作者：
CHUGANI, HT;PHELPS, ME
2-脱氧-2 [18F]氟-D-葡萄糖正电子发射断层扫描显示，在人类婴儿发育过程中，局部脑葡萄糖利用的变化。在5周龄及以下的婴儿中，葡萄糖利用率在感觉运动皮层、丘脑、中脑-脑干和小脑蚓部最高。到3个月时，顶叶、颞叶、枕叶皮质和基底神经节的葡萄糖代谢活动增加，随后在8个月时额叶和各种相关区域增加。正电子发射断层扫描测量的这些功能变化与已知在婴儿发育期间发生的行为，神经生理和解剖学改变一致。
2-Deoxy-2[18F]fluoro-D-glucose positron emission tomography performed in human infants during development revealed progessive changes in local cerebral glucose utilization. In infants 5 weeks of age and younger, glucose utilization was highest in the sensorimotor cortex, thalamus, midbrain-brainstem, and cerebellar vermis. By 3 months, glucose metabolic activity had increased in the parietal, temporal, and occipital cortices and the basal ganglia, with subsequent increases in frontal and various association regions occurring by 8 months. These functional changes measured with positron emission tomography are in agreement with behavioral, neurophysiological, and anatomical alterations known to occur during infant development.