Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma
Association of estradiol and HPV/HPV16 infection with the occurrence of cervical squamous cell carcinoma
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雌二醇、HPV/HPV16感染与宫颈鳞癌发生的关系
DOI：
10.3892/ol.2019.10005
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发表时间：
2019-03-01
期刊：
影响因子：
2.9
通讯作者：
Wang, Jintao
中科院分区：
文献类型：
--
作者：
Ding, Ling;Liu, Chunliang;Wang, Jintao
The associations between human papillomavirus (HPV) infection or hormonal exposure and cervical cancer risk are well established. However, to the best of our knowledge, the association between high endogenous estradiol levels in conjunction with HPV/HPV16 infection and the risk of cervical squamous cell carcinoma remains unknown. To investigate this, the current study conducted a matched case-control study in Shanxi Province, China, in which clinical samples were obtained from 74 females with newly diagnosed uterine cervix squamous cell carcinoma and 74 matched healthy females who were selected from 582 healthy females according to age, place of residence, marital status and menopausal status. From all participants, DNA was extracted from cells obtained from a cervical smear and serum was separated from venous blood withdrawn during days 5-8 of the menstrual cycle. HPV/HPV16 DNA and estradiol expression levels in the serum were measured by general polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Significant differences were identified in the positive HPV and HPV16 DNA expression rates between patients and controls, with odds ratios (95% confidence interval) of 3.74 (1.84-7.59) and 4.04 (1.97-8.28), respectively. Expression levels of estradiol in patients were significantly higher compared with the controls (P
