Systolic direct ventricular interaction affects left ventricular contraction and relaxation in the intact dog circulation.
Systolic direct ventricular interaction affects left ventricular contraction and relaxation in the intact dog circulation.
复制标题
收缩期直接心室相互作用影响完整狗循环中的左心室收缩和舒张。
DOI：
10.1161/01.res.65.2.307
复制
发表时间：
1989
影响因子：
20.1
通讯作者：
LeWinter,MM
中科院分区：
文献类型：
--
作者：
Slinker,BK;Goto,Y;LeWinter,MM
右室收缩功能的改变直接影响左室收缩功能。我们对这种收缩期直接心室相互作用的认识大多来自于离体心脏的研究，这些研究表明，右心室大小的变化仅在低压和低容量时影响左心室收缩功能。然而，几乎没有什么是已知的收缩直接心室相互作用的心脏功能在原位的一部分，完整的循环。我们使用肺动脉的突然收缩来评估右心室压力和收缩模式的变化对麻醉开胸犬肺动脉收缩后左心室收缩和舒张的即时影响。通过关注第一次搏动，我们能够避免系列心室相互作用的混淆效应，这种相互作用改变了左心室充盈，从而间接影响了左心室功能。基线左心室舒张末期压为9.6 +/- 2.1 mm Hg（平均值+/- SD），突然肺动脉收缩使左心室收缩压峰值增加3 +/- 2 mm Hg（2%变化），左心室每搏输出量增加2 +/- 2 ml（8%变化），以及舒张期间左心室压力下降的单指数时间常数为9 +/-6 msec（22%变化）。这种增加的左心室舒张时间常数与舒张过程中左心室后壁和前壁游离壁的局部节段长度变化有关。我们的结论是，收缩期直接心室相互作用影响左心室收缩功能和舒张在正常条件下，在完整的循环。
Changes in right ventricular systolic function directly influence left ventricular systolic function. Most of our knowledge of this systolic direct ventricular interaction comes from studies of isolated hearts, which suggest that changes in right ventricular size only affect left ventricular systolic function at low pressures and volumes. However, almost nothing is known about systolic direct ventricular interaction in a heart functioning in situ as a part of the intact circulation. We used sudden constriction of the pulmonary artery to assess the immediate effect of a change in right ventricular pressure and contraction pattern on left ventricular contraction and relaxation on the beat following the pulmonary artery constriction in anesthetized open-chest dogs. By focusing on this first beat, we were able to avoid the confounding effect of series ventricular interaction, which changes left ventricular filling and, thus, indirectly influences left ventricular function. At baseline left ventricular end-diastolic pressure of 9.6 +/- 2.1 mm Hg (mean +/- SD), sudden pulmonary artery constriction increased left ventricular peak systolic pressure by 3 +/- 2 mm Hg (2% change), left ventricular stroke volume by 2 +/- 2 ml (8% change), and monoexponential time constant of left ventricular pressure fall during relaxation by 9 +/- 6 msec (22% change). This increased left ventricular relaxation time constant was associated with altered regional segment length changes in the posterior and anterior left ventricular free walls during relaxation. We conclude that systolic direct ventricular interaction affects left ventricular systolic function and relaxation under normal conditions in the intact circulation.