Retinal pigment epithelium melanin distribution estimated by polarisation entropy and its association with retinal sensitivity in patients with high myopia
Retinal pigment epithelium melanin distribution estimated by polarisation entropy and its association with retinal sensitivity in patients with high myopia
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DOI：
10.1136/bjophthalmol-2021-318890
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发表时间：
2021-05-05
影响因子：
4.1
通讯作者：
Kato, Satoshi
中科院分区：
文献类型：
--
作者：
Harimoto, Akira;Obata, Ryo;Kato, Satoshi
目的应用偏振敏感光学相干断层扫描（PS-OCT）技术研究高度近视眼视网膜敏感性与视网膜色素上皮（RPE）黑色素分布等解剖学特征的关系。设计回顾性连续观察性队列研究。方法我们纳入了来自东京大学医院患者的高度近视眼（屈光不正= 26.5 mm）。视网膜敏感性通过微视野计在距中央凹6度内的25个扇区处测量。去偏振值，反映黑色素沉着，测量的PS-OCT的临床原型，并作为偏振熵参数化。将高度近视患者的视网膜敏感度或RPE处的熵与正视眼对照组进行比较。视网膜敏感度与年龄、眼轴长度、熵或脉络膜厚度的相关性在每只眼和每扇区分析中进行评估。结果23只高度近视眼（年龄66.6 ± 12.3岁）。平均视网膜敏感度为25.3 ± 3.0 dB，与对照组相比显著降低（p
Purpose To investigate retinal sensitivity of highly myopic eyes without choroidal neovascularisation (CNV) or patchy chorioretinal atrophy (PCA) and investigated its association with anatomical characteristics including melanin distribution at the retinal pigment epithelium (RPE), which was evaluated with polarisation-sensitive optical coherence tomography (PS-OCT). Design Retrospective consecutive observational cohort study. Methods We included highly myopic eyes (refractive error = 26.5 mm) from patients at the University of Tokyo Hospital. Retinal sensitivity was measured by microperimetry at 25 sectors within 6 degrees from the fovea. Depolarisation value, which reflected melanin pigmentation, was measured by a clinical prototype of PS-OCT and was parameterised as polarimetric entropy. Retinal sensitivity or entropy at the RPE in high myopia was compared with emmetropic control subjects. The association of retinal sensitivity with age, axial length, entropy, or choroidal thickness was assessed in per-eye and per-sector analysis. Results Twenty-three highly myopic eyes (age, 66.6 +/- 12.3 years) were included. The average retinal sensitivity was 25.3 +/- 3.0 dB, which was significantly decreased compared with the control (p