Tn antigen interactions of macrophage galactose-type lectin (MGL) in immune function and disease.
Tn antigen interactions of macrophage galactose-type lectin (MGL) in immune function and disease.
复制标题
巨噬细胞半乳糖型凝集素 (MGL) 在免疫功能和疾病中的 Tn 抗原相互作用。
DOI：
10.1093/glycob/cwad083
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发表时间：
2023
期刊：
影响因子：
4.3
通讯作者：
Avci,FikriY
中科院分区：
文献类型：
--
作者：
Tumoglu,Berna;Keelaghan,Aidan;Avci,FikriY
蛋白质-碳水化合物的相互作用在维持免疫平衡和协调炎症和调节免疫过程中是必不可少的。本文就巨噬细胞半乳糖型凝集素(MGL，CD301)与TN糖类抗原的免疫相互作用作一综述。MGL是一种C型凝集素受体(CLR)，主要由巨噬细胞和未成熟树突状细胞等髓系细胞表达。MGL识别表面蛋白上的末端O-连接N-乙酰半乳糖胺(GalNAc)残基，也称为TN抗原(TN)。TN是细长的细胞表面O-多糖的截断形式。当负责O-糖链延长的酶-T-合成酶-或与其相关的伴侣-Cosmc-被功能性抑制时，可能会发生导致TN的低糖基化。本文综述了TN在许多不同的肿瘤和非肿瘤疾病中的表达，MGL对TN的识别在调节效应性T细胞、免疫抑制和病原体识别方面发挥了重要作用。
Protein-carbohydrate interactions are essential in maintaining immune homeostasis and orchestrating inflammatory and regulatory immune processes. This review elucidates the immune interactions of macrophage galactose-type lectin (MGL, CD301) and Tn carbohydrate antigen. MGL is a C-type lectin receptor (CLR) primarily expressed by myeloid cells such as macrophages and immature dendritic cells. MGL recognizes terminal O-linked N-acetylgalactosamine (GalNAc) residue on the surface proteins, also known as Tn antigen (Tn). Tn is a truncated form of the elongated cell surface O-glycan. The hypoglycosylation leading to Tn may occur when the enzyme responsible for O-glycan elongation—T-synthase—or its associated chaperone—Cosmc—becomes functionally inhibited. As reviewed here, Tn expression is observed in many different neoplastic and non-neoplastic diseases, and the recognition of Tn by MGL plays an important role in regulating effector T cells, immune suppression, and the recognition of pathogens.