The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity
The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity
复制标题
DOI：
10.1016/s0969-2126(03)00095-9
复制
发表时间：
2003-06-01
期刊：
影响因子：
5.7
通讯作者：
Bordo, D
中科院分区：
文献类型：
--
作者：
Cantoni, C;Ponassi, M;Bordo, D
自然杀伤（NK）细胞直接杀伤肿瘤或病毒感染细胞。NK细胞的激活依赖于抑制受体和激活受体之间的良好平衡。NKp44是一种细胞毒性激活受体，由一个igg样胞外结构域、一个跨膜段和一个细胞质结构域组成。2.2埃晶体结构表明，NKp44 Ig结构域形成鞍形二聚体，每个亚基的核心结构中都有一个带电表面凹槽突出。NKp44 Ig结构域二硫化桥拓扑定义了一个新的Ig结构亚族。提出的数据是了解天然细胞毒性受体识别配体的分子基础的第一步，其在免疫系统中的关键作用是确定的，但其细胞配体仍然难以捉摸。
Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 Angstrom crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.