Childhood predictors of written expression in late adolescents with 22q11.2 deletion syndrome: a longitudinal study
Childhood predictors of written expression in late adolescents with 22q11.2 deletion syndrome: a longitudinal study
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DOI：
10.1111/jir.12370
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发表时间：
2017-05-01
影响因子：
3.6
通讯作者：
Kates, W. R.
中科院分区：
文献类型：
--
作者：
Hamsho, N.;Antshel, K. M.;Kates, W. R.
背景22q11.2缺失综合征（22 q11 DS）是第二大流行的遗传综合征，具有特征性的学业和行为表型。本研究的主要目的是探讨22 q11 DS青少年书面表达成绩的儿童期预测因素。书面表达是一个重要的技能，可以影响一个人的整体学习成绩，可能会导致压力水平的增加和精神症状的恶化。69名患有22 q11 DS的晚期青少年和50名对照（包括23名患有22 q11 DS的未受影响的青少年兄弟姐妹和27名社区对照）参加了一项为期6年的纵向研究项目，每3年接受一次神经心理测试。Wechsler个人成就测验-第二版的书面表达分测验是主要的成果措施，在当前的project.Results调查结果表明，在22 q11 DS组和对照组的参与者之间的青少年书面表达的儿童预测差异。儿童期言语智商分数预测对照组青少年书面表达，而儿童期执行功能和语言技能是22 q11 DS个体青少年书面表达的唯一预测因子。结论22 q11 DS儿童期青少年晚期书面表达的预测因子与非22 q11 DS人群中的预测因子存在显著差异。这些结果提供了一些指导的潜在因素，可能是有用的，以考虑在制定书面表达干预与22 q11 DS儿童。
Background 22q11.2 deletion syndrome (22q11DS) is the second most prevalent genetic syndrome and has a characteristic academic and behavioural phenotype. The primary objective of the current study was to examine the childhood predictors of written expression achievement in adolescents with 22q11DS. Written expression is an important skill that can impact an individual's overall academic performance, potentially resulting in increased levels of stress and exacerbation of psychiatric symptoms.Methods A total of 119 participants were included in this study. Sixty-nine late adolescents with 22q11DS and 50 controls (consisting of a combined sample of 23 unaffected siblings of youth with 22q11DS and 27 community controls) participated in a 6-year longitudinal research project and received neuropsychological test batteries every 3years. The Written Expression subtest of the Wechsler Individual Achievement Test - Second Edition was the primary outcome measure in the current project.Results Findings indicated differences in childhood predictors of adolescent written expression between participants in the 22q11DS group and participants in the control group. Whereas childhood verbal IQ scores predicted adolescent written expression for participants in the control group, childhood executive function and language skills were unique predictors of adolescent written expression in individuals with 22q11DS.Conclusions Childhood predictors of late adolescent written expression in 22q11DS differ in meaningful ways from predictors in the non-22q11DS population. These results offer some guidance on the underlying factors that may be useful to consider when developing written expression interventions for children with 22q11DS.