The red head and neck of Boer goats may be controlled by the recessive allele of the MC1R gene
The red head and neck of Boer goats may be controlled by the recessive allele of the MC1R gene
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波尔山羊的红色头颈可能是由MC1R基因的隐性等位基因控制的
DOI：
10.1051/animres:2006020
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发表时间：
2006-07
期刊：
影响因子：
--
通讯作者：
Tian-Rong XIN
中科院分区：
文献类型：
--
作者：
Zhao-Long WU;Xiang-Long LI;Yuan-Fang GONG;Qing JI;Yan-Qiang LIU;Zheng-Zhu LIU;Xiao-Juan WANG;Tian-Rong XIN
黑素皮质素-1受体(MC1R)基因是毛色性状的重要候选基因。为了解波尔山羊红头颈的分子遗传基础，采用聚合酶链式反应-限制性片段长度多态性技术对波尔山羊与唐山奶山羊回交后代(F1、F2、F3、F4)等26个山羊群体、18个中国主要地方山羊品种和4个引进山羊品种(共319个)的MC1R基因多态性进行了比较分析。检测到A、B两个等位基因，AA、AB、BB三种基因型。测序发现MC1R基因K226E(A676G)突变可区分B等位基因和A等位基因。在波尔山羊中发现的唯一AA基因型与其红色的头和脖子是一致的。卡方检验表明，波尔山羊的红头颈可能受MC1R基因的隐性A等位基因控制。然而，B等位基因的K226E可能是与山羊全白毛相关的功能缺失突变。波尔山羊/红头颈/MC1R基因/K226E突变/白大衣
T heMelanocortin-1-receptor (MC1R) gene is an important candidate gene for the coat color trait. In order to understand the molecular genetic basis of the red head and neck of Boer goats, a comparative analysis of MC1R gene polymorphism in imported foreign breed Boer goats and another 26 goat populations including Boer goat offspring backcrossed to Tangshan Dairy goats (F1, F2, F3 and F4), 18 Chinese main indigenous goat breeds and four other imported foreign goat breeds (including a total of 319 individuals) were analyzed by PCR-RFLP. Two alleles of A and B, and three genotypes of AA, AB and BB were detected. The K226E (A676G) mutation of the MC1R detected by sequencing distinguished the B allele from the A allele. The only AA genotype found in Boer goats was complete in accordance with their red head and neck. The Chi-square test suggested that the red head and neck of Boer goats may be controlled by the recessive A allele of the MC1R gene. However, the K226E at the B allele may be a loss of function mutation associated with the whole white coat of goats. Boer goat / red head and neck / MC1R gene / K226E mutation / white coat
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DOI：
--
发表时间：
2002-11
期刊：
Yi chuan = Hereditas
影响因子：
--
作者：
Xianglong Li;Y. Gong;Zheng-zhu Liu;Xiu-li Han
通讯作者：
Xianglong Li;Y. Gong;Zheng-zhu Liu;Xiu-li Han
DOI：
10.1111/j.1749-6632.2003.tb03194.x
发表时间：
2003-06
影响因子：
5.2
作者：
N. Mundy;Joanne Kelly;E. Theron;K. Hawkins
通讯作者：
N. Mundy;Joanne Kelly;E. Theron;K. Hawkins
影响因子：
2.5
作者：
Våge, DI;Klungland, H;Cone, RD
通讯作者：
Cone, RD
影响因子：
2.4
作者：
Kerje, S;Lind, J;Andersson, L
通讯作者：
Andersson, L
影响因子：
2.5
作者：
Schmutz, SM;Berryere, TG;Goldfinch, AD
通讯作者：
Goldfinch, AD