Theranostic radioiodine-labelled melanin nanoparticles inspired by clinical brachytherapy seeds
Theranostic radioiodine-labelled melanin nanoparticles inspired by clinical brachytherapy seeds
复制标题
受临床近距离放射治疗种子启发的治疗诊断放射性碘标记黑色素纳米颗粒
DOI：
10.1039/c8tb02817f
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发表时间：
2018
影响因子：
7
通讯作者：
Yang Min
中科院分区：
文献类型：
--
作者：
Sheng Jie;Wang Xinyu;Yan Junjie;Pan Donghui;Yang Runlin;Wang Lizhen;Xu Yuping;Yang Min
放射性碘广泛应用于核医学，主要作为示踪剂和治疗剂，并得益于其碘的多种放射性同位素，包括I-123、I-124、I-125、I-131等。黑色素是一种天然物质，广泛分布于人体皮肤、头发和眼睛中。黑色素具有良好的生物相容性和多功能性，使其成为生物医学应用的理想载体。在这里，我们通过一种新的Ag-I两步法制备了放射性碘标记的黑色素纳米颗粒（MNP）。Ag-I标记法用于MNP放射性碘标记具有标记时间快、标记产率高、稳定性好等优点。所获得的MNP-Ag-131 I可用于单光子发射计算机断层扫描和切伦科夫辐射成像。131 I的β射线也使其成为癌细胞杀手的良好候选者。该纳米颗粒的治疗诊断特性也在体内异种移植肿瘤模型中得到证实。总之，这项研究为放射性碘标记纳米颗粒提供了一个新的概念，可以进一步研究不同放射性碘同位素在各种成像和放射治疗中的应用。
Radioiodine is widely used in nuclear medicine, mainly serving as a tracer and therapeutic agent, and benefits from its various radioactive isotopes of iodine including I-123, I-124, I-125, I-131 and so on. Melanin is a natural material widely dispersed in the human skin, hair and eyes. The excellent biocompatibility and multifunctional abilities of melanin make it a perfect carrier for biomedical applications. Here, we fabricated theranostic radioiodine-labelled melanin nanoparticles (MNPs) through a novel Ag–I two-step method. The Ag–I labelling method for MNP radioiodine-labelling has advantages including a faster labelling time, higher labelling yield, and higher stability than the chloramine-T oxidation method reported previously. The obtained MNP–Ag–131I can be used for both single-photon emission computed tomography and Cherenkov radiation imaging. The β-rays of 131I also make it a good candidate as a cancer cell killer. The theranostic properties of this nanoparticle were also proved in a xenograft tumor model in vivo. In summary, this study provides a new concept for radioiodine labelling nanoparticles, which can be further investigated in various imaging and radiotherapy applications with different radioactive isotopes of iodine.