Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
Genetic and environmental influences on adult human height across birth cohorts from 1886 to 1994
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DOI：
10.7554/elife.20320
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发表时间：
2016-12-14
期刊：
影响因子：
7.7
通讯作者：
Silventoinen, Karri
中科院分区：
文献类型：
--
作者：
Jelenkovic, Aline;Hur, Yoon-Mi;Silventoinen, Karri
人类身高的变化是由遗传和环境因素决定的，但目前还不清楚它们的影响是否在不同出生年份的人群中有所不同。我们对40对双胞胎队列进行了基于个体的汇总分析，其中包括143,390对出生于18861994年的完整双胞胎。尽管遗传变异在出生年份队列中显示出普遍增加的趋势，但遗传力估计（男性0.69-0.84，女性0.53-0.78）并没有显示出任何明确的长期变化模式。比较地理文化区域（欧洲、北美和澳大利亚以及东亚），北美和澳大利亚的总身高差异最大，东亚最小，但在出生年份队列的遗传力估计中没有明确的模式。我们的研究结果并不支持以下假设，即生活水平低的人群的身高遗传率低于富裕人群，也不支持随着生活水平的提高，身高遗传率会在人群中增加。
Human height variation is determined by genetic and environmental factors, but it remains unclear whether their influences differ across birth-year cohorts. We conducted an individual-based pooled analysis of 40 twin cohorts including 143,390 complete twin pairs born 18861994. Although genetic variance showed a generally increasing trend across the birth-year cohorts, heritability estimates (0.69-0.84 in men and 0.53-0.78 in women) did not present any clear pattern of secular changes. Comparing geographic-cultural regions (Europe, North America and Australia, and East Asia), total height variance was greatest in North America and Australia and lowest in East Asia, but no clear pattern in the heritability estimates across the birth-year cohorts emerged. Our findings do not support the hypothesis that heritability of height is lower in populations with low living standards than in affluent populations, nor that heritability of height will increase within a population as living standards improve.