Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201
Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201
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DOI：
10.1038/s41429-020-00386-y
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发表时间：
2020-12-14
影响因子：
3.3
通讯作者：
Liu，Yonghong
中科院分区：
文献类型：
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作者：
Yang，Bin;Long，Jieyi;Liu，Yonghong
从软珊瑚共生真菌StachybobocyanchartarumSCSIO 41201中分离得到四种未描述的聚酮衍生物，命名为arthproliferinA-D（1-4），一种未描述的苯基螺环烷衍生物，命名为arthproliferinE（7），沿着11种已知代谢产物（5，6，8 -16）。通过光谱学方法、X射线晶体学和ECD分析确定了它们的结构。评价化合物1和3 - 15的细胞毒性和抗菌活性。其中化合物1和15对耐甲氧西林金黄色葡萄球菌ATCC 29213表现出中等抑制活性，MIC值分别为78和39 μg/mL。此外，化合物15对测试的细胞系显示出强的细胞毒活性，IC 50值小于39 nM。
Four undescribed polyketide derivatives, named arthproliferins A–D (1–4), and one undescribed phenylspirodrimane derivative, named arthproliferin E (7), along with 11 known metabolites (5,6,8–16) were isolated from the soft coral-associated fungusStachybotrys chartarumSCSIO41201. Their structures were determined through spectroscopic methods, X-ray crystallography, and ECD analysis. Compounds1and3–15were evaluated for their cytotoxic, and antibacterial activities. Among them, compounds1and15displayed moderate inhibitory activity against methicillin-resistantStaphylococcus aureusATCC 29213 with an MIC value of 78 and 39 µg/mL, respectively. Furthermore, compound15displayed strong cytotoxic activities against the tested cell line with IC50values less than 39 nM.