Adipose tissue-derived autotaxin causes cardiomyopathy in obese mice
Adipose tissue-derived autotaxin causes cardiomyopathy in obese mice
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DOI：
10.1530/jme-18-0242
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Yu Bo
中科院分区：
文献类型：
--
作者：
Xu yousheng;Wang yongshun;Liu jingjin;Cao wei;Li lili;Du hongwei;Zhan enbo;Zhang ruoxi;Liu huimin;Qu yilin;Yu Bo
The prevalence of obesity is dramatic increased and strongly associated with.cardiovascular disease. Adipokines, secreted from adipose tissues, are critical risk.factors for the development of cardiomyopathy. Present study aimed to investigate the.pathophysiological role of autotaxin in obesity-related cardiomyopathy. In high-fat dietfed mice, autotaxin was mainly synthesized and secreted from adipocytes. The increased.accumulation of cardiac autotaxin was positively associated with cardiac dysfunction.in obese mice. Interestingly, specifc blockage of adipose tissue autotaxin effectively.protected against high-fat diet-induced cardiac structural disorders, left ventricular.hypertrophy and dysfunction. Inhibition of autotaxin further improved high-fat dietinduced cardiac fbrosis and mitochondrial dysfunction, including improvement of.mitochondrial structure, mass and activities. Our fndings demonstrated intervention of.adipose tissue biology could influence cardiac modifcation in obese mice, and adipocytederived autotaxin was a potential diagnostic marker and therapeutic target for obesityrelated cardiomyopathy.
