Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis.
Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis.
复制标题
终末期肺纤维化患者吸入一氧化氮可改善肺动脉高压和低氧血症。
DOI：
10.1164/ajrccm.149.3.8118653
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发表时间：
1994
影响因子：
24.7
通讯作者：
C. M. Smith
中科院分区：
文献类型：
--
作者：
R. Channick;R. C. Hoch;J. Newhart;F. Johnson;C. M. Smith
一位患有严重肺间质纤维化、低氧血症、肺动脉高压和肺心病的患者接受吸入一氧化氮（NO），然后静脉注射PGE1，以评估肺动脉高压的可逆性。在吸入NO期间，肺血管阻力显著降低，心输出量增加，动脉氧合显著改善。对全身血管阻力无影响。相反，静脉注射PGE1导致动脉血氧饱和度迅速下降，呼吸困难加重。该患者吸入NO的有益反应表明，即使在严重的慢性肺病中，也存在可逆的肺血管收缩。因此，吸入NO作为一种选择性肺血管扩张剂在肺间质纤维化和肺心病患者中具有潜在的治疗作用。
A patient with severe interstitial pulmonary fibrosis, hypoxemia, pulmonary hypertension, and cor pulmonale was given inhaled nitric oxide (NO) followed by intravenous PGE1 to assess the reversibility of pulmonary hypertension. During NO inhalation, there was marked reduction in pulmonary vascular resistance, increased cardiac output, and dramatic improvement in arterial oxygenation. There was no effect on systemic vascular resistance. In contrast, intravenous PGE1 led to rapid arterial oxygen desaturation and worsened dyspnea. The beneficial responses to inhaled NO in this patient suggest that, even in severe chronic lung disease, reversible pulmonary vasoconstriction is present. Inhaled NO thus has a potential therapeutic role as a selective pulmonary vasodilator in patients with interstitial pulmonary fibrosis and cor pulmonale.
影响因子：
158.5
作者：
ROSSAINT, R;FALKE, KJ;ZAPOL, WM
通讯作者：
ZAPOL, WM