CORRECTED GROUP PROGNOSTIC CURVES AND SUMMARY STATISTICS
CORRECTED GROUP PROGNOSTIC CURVES AND SUMMARY STATISTICS
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DOI：
10.1016/0021-9681(82)90019-4
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发表时间：
1982-01-01
期刊：
影响因子：
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通讯作者：
PAGANO, M
中科院分区：
文献类型：
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作者：
CHANG, IM;GELMAN, R;PAGANO, M
提出了一种校正分布函数估计量的方法，用于校正不同处理子样本中协变量联合分布的畸变。这种形式的标准化对于描述多变量分析和预测人口行为很有用。它也被证明是有用的比较两个试验不同的患者组合和调整估计已知的不平衡的患者特征。标准化虽然很重要，但由于多协变量引入的复杂性，在临床试验中并不常用。所提出的方法克服了在广泛的分析类中的这些困难。
A method is presented for correcting distribution function estimators for distortions in the joint distribution of covariates in the subsamples receiving different treatments. This form of standardization is useful for depicting multivariate analyses and predicting population behavior. It also proves useful for comparing 2 trials which differ in patient mix and for adjusting estimates for known imbalances in patient characteristics. Standardization, though important, is not often used in clinical trials because of the complexities introduced by multiple covariates. The proposed method overcomes these difficulties in a wide class of analyses.