Dynamic liver imaging with iron oxide agents: effects of size and biodistribution on contrast.
Dynamic liver imaging with iron oxide agents: effects of size and biodistribution on contrast.
复制标题
使用氧化铁剂进行动态肝脏成像：大小和生物分布对对比度的影响。
DOI：
10.1002/mrm.1910370613
复制
发表时间：
1997
影响因子：
3.3
通讯作者：
Weisskoff,RM
中科院分区：
文献类型：
--
作者：
Mandeville,JB;Moore,J;Chesler,DA;Garrido,L;Weissleder,R;Weisskoff,RM
In vivoeffective relaxation rates in normal rat liver were evaluated for four dextran coated iron oxide agents: monocrystal‐line iron oxide nanocolloid (MION) with a mean particle diameter of 3.9 nm, a polycrystalline agent (PION) with a larger mean diameter of 12 nm, and these two agents labeled with the asialofetuin (ASF) protein for high hepatocytic receptor binding affinity (MION‐ASF and PION‐ASF). Using echo planar imaging at 2 Tesla, dose response was measured with high temporal resolution for 3 h after injection of agent, and by comparing with relaxivitiesin vitroand in brain, dominantin vivocontrast phenomena were elucidated. While transverse relaxivity for PION‐ASF exceeded that for MION‐ASF by almost a factor of 2 in solution, relaxation ratesin vivobecame equivalent. Liver relaxation using non‐ASF agents was consistent with rapid water exchange between vascular and extravascular compartments, which dominated relaxation as a result of agent accumulation in Kupffer cells.
