EVIDENCE FOR MODULATION OF MELATONIN SECRETION IN MEN WITH BENIGN AND MALIGNANT-TUMORS OF THE PROSTATE - RELATIONSHIP WITH THE PITUITARY-HORMONES
EVIDENCE FOR MODULATION OF MELATONIN SECRETION IN MEN WITH BENIGN AND MALIGNANT-TUMORS OF THE PROSTATE - RELATIONSHIP WITH THE PITUITARY-HORMONES
复制标题
DOI：
10.1111/j.1600-079x.1985.tb00633.x
复制
发表时间：
1985-01-01
影响因子：
10.3
通讯作者：
GUPTA, D
中科院分区：
文献类型：
--
作者：
BARTSCH, C;BARTSCH, H;GUPTA, D
在患有不同类型前列腺肿瘤的老年男性中，通过放射免疫测定法 (RIA) 在 24 小时内每隔 4 小时测定松果体激素褪黑激素的血清水平：良性前列腺增生 (BPH，n = 13)、偶发性癌 (PCi，n = 5) 和非转移性癌 (PC，n = 9) 以及年轻男性 (YM，n = 10)。同时，用放射免疫分析法测定垂体激素催乳素、生长激素、黄体生成素和FSH。所有受试者均未接受治疗，也没有严重的不适，并处于相同的环境中。数据采用总体均值余弦法进行分析；计算每组5种激素之间的线性相关系数。褪黑激素在年轻男性以及 BPH 和 PCi 患者中显示出显着的昼夜节律，但在 PC 患者中则不然；与 PC 患者相比，PCi 患者的 24 小时平均浓度（mesor）和波幅显着增加。年轻男性和 BPH 患者的催乳表现出明显的昼夜节律； PCi 和 PC 患者似乎有超电变化。生长激素在任何组中均未表现出明显的节律；与年轻男性相比，所有肿瘤组的中值均升高。与年轻男性相比，所有肿瘤患者的促性腺激素中值均升高；未检测到节律。癌症患者表现出与所有其他群体不同的激素间相关性。褪黑激素分泌的调节，伴随着垂体激素水平的变化，显然可能与前列腺癌的发生和生长有关。
Serum levels of the pineal hormone melatonin were determined by radioimmunoassay (RIA) in 4 h intervals throughout a 24 h period in elderly men with different types of prostate tumors: benign prostatic hyperplasia (BPH, n = 13), incidental carcinoma (PCi, n = 5) and nonmetastasizing carcinoma (PC, n = 9) and in young men (YM, n = 10). Simultaneously, the pituitary hormones prolactin, growth hormone, luteinizing hormone and FSH were measured by RIA. All subjects were untreated and free of serious complaints and stayed in the same enviroment. Data were analyzed by the population mean-cosinor method; linear correlation coefficients between the 5 hormones were calculated for each group. Melatonin showed significant circadian rhythms in young men and patients with BPH and PCi but not in patients with PC; 24-h mean concentration (mesor) and amplitude were significantly increased in patients with PCi as compared to patients with PC. Prolaction showed significant circadian rhythms in young men and in patients with BPH; patients with PCi and PC appeared to have ultradian variations. Growth hormone did not show significant rhythms in any group; mesors were elevated in all tumor groups as compared to young men. Gonadotropin mesors were elevated in all tumor patients as compared to young men; rhythms were not detected. Carcinoma patients showed different interhormonal correlations than all other groups. Modulation of melatonin secretion, accompanied by changes in the pituitary hormone levels, may evidently be related to development and growth of prostate cancer.