ALTERED EXERCISE GAS-EXCHANGE AND CARDIAC-FUNCTION IN PATIENTS WITH MILD CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
ALTERED EXERCISE GAS-EXCHANGE AND CARDIAC-FUNCTION IN PATIENTS WITH MILD CHRONIC OBSTRUCTIVE PULMONARY-DISEASE
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DOI：
10.1378/chest.103.3.745
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发表时间：
1993-03-01
期刊：
影响因子：
9.6
通讯作者：
HOLIDAY, D
中科院分区：
文献类型：
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作者：
CARTER, R;NICOTRA, B;HOLIDAY, D
晚期COPD患者气体交换和肺功能明显降低；然而，对轻度COPD患者的体力工作能力和运动气体交换知之甚少。共有39名无COPD证据的个体（20名男性和19名女性）（对照组）和51名轻度COPD患者（29名男性和22名女性）（FEV1大于或等于预测的60%；FEV1与强迫肺活量的比率为60%至70%）进行了测试，以确定对进行性最大周期测力仪测试的静息肺功能和静息和峰值运动气体交换。一般来说，与对照组相比，轻度COPD患者有相似的吸烟史和基本相同的静息气体交换研究。测定的最大耗氧量在两种雄性动物中均较低(p
Patients with advanced COPD have significantly reduced gas exchange and pulmonary function; however, little is known regarding physical work capacity and exercise gas exchange in patients with mild COPD. A total of 39 individuals (20 men and 19 women) without evidence of COPD (controls) and 51 individuals (29 men and 22 women) with mild COPD (FEV1 greater-than-or-equal-to 60 percent of predicted; and ratio of FEV1 over forced vital capacity of 60 to 70 percent) were tested to determine resting pulmonary function and resting and peak exercise gas exchange in response to progressive maximal cycle ergometer testing. In general, those with mild COPD had similar smoking histories and essentially equivalent resting gas exchange studies as compared to the controls. Measured maximal oxygen consumption was less in both the male (p