Defining Treatment Response in Pediatric Tic Disorders: A Signal Detection Analysis of the Yale Global Tic Severity Scale
Defining Treatment Response in Pediatric Tic Disorders: A Signal Detection Analysis of the Yale Global Tic Severity Scale
复制标题
DOI：
10.1089/cap.2010.0149
复制
发表时间：
2011-12-01
影响因子：
1.9
通讯作者：
Murphy, Tanya K.
中科院分区：
文献类型：
--
作者：
Storch, Eric A.;De Nadai, Alessandro S.;Murphy, Tanya K.
目的：研究最佳耶鲁大学全球抽动严重程度量表（YGTSS）的百分比减少和原始cutoffs预测儿童和青少年抽动disorders.Method治疗反应：青少年抽动障碍（N = 108;范围= 5-17岁）参加了几个临床试验，涉及各种药物或心理治疗，或接受自然护理。在治疗前后进行评估，包括YGTSS和临床疗效总评量表（CGI-I）的反应状态。结果：YGTSS总抽动严重程度评分降低35%或YGTSS原始总抽动严重程度评分变化6或7分是青少年抽动障碍临床治疗反应的最佳指标。YGTSS总抽动严重程度评分降低35%或原始总抽动严重程度评分变化6或7似乎是确定治疗反应的最佳选择。YGTSS中治疗应答的一致定义可能有助于交叉研究的可比性。医生可以使用这些值进行治疗计划决策（e。例如，在一个实施例中，换药等）。
Objective: To examine the optimal Yale Global Tic Severity Scale (YGTSS) percent reduction and raw cutoffs for predicting treatment response among children and adolescents with tic disorders.Method: Youth with a tic disorder (N = 108; range = 5-17 years) participated in several clinical trials involving varied medications or psychosocial treatment, or received naturalistic care. Assessments were conducted before and after treatment and included the YGTSS and response status on the Clinical Global Impressions-Improvement Scale (CGI-I).Results: A 35% reduction on the YGTSS total tic severity score or a YGTSS raw total tic severity score change of 6 or 7 points were the best indicators of clinical treatment response in youth with tic disorders.Conclusions: A YGTSS total tic severity score reduction of 35% or a raw total tic severity score change of 6 or 7 appears optimal for determining treatment response. A consistent definition of treatment response on the YGTSS may facilitate cross-study comparability. Practitioners can use these values for treatment planning decisions (e. g., change medications, etc.).