DEVELOPMENT OF TH1 CD4+ T-CELLS THROUGH IL-12 PRODUCED BY LISTERIA-INDUCED MACROPHAGES
DEVELOPMENT OF TH1 CD4+ T-CELLS THROUGH IL-12 PRODUCED BY LISTERIA-INDUCED MACROPHAGES
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DOI：
10.1126/science.8097338
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发表时间：
1993-04-23
期刊：
影响因子：
56.9
通讯作者：
MURPHY, KM
中科院分区：
文献类型：
--
作者：
HSIEH, CS;MACATONIA, SE;MURPHY, KM
在免疫应答过程中，适当的CD4+ T辅助（T(H)）亚群的发展对疾病的解决是重要的。利用未成熟的卵清蛋白特异性α T细胞受体转基因T细胞，发现热杀伤单核增生李斯特菌通过巨噬细胞产生白细胞介素-12 （IL-12）诱导T(H)1在体外发育。此外，抑制巨噬细胞产生IL-12可能解释了IL-10抑制T(H)1发育的能力。小鼠体内对单核增生乳杆菌的免疫反应具有适当的T(H)1表型。因此，这种调节途径可能已经进化到使先天免疫细胞通过与微生物病原体的相互作用，将特异性免疫的发展导向适当的T(H)表型。
Development of the appropriate CD4+ T helper (T(H)) subset during an immune response is important for disease resolution. With the use of naive, ovalbumin-specific alphabeta T cell receptor transgenic T cells, it was found that heat-killed Listeria monocytogenes induced T(H)1 development in vitro through macrophage production of interleukin-12 (IL-12). Moreover, inhibition of macrophage production of IL-12 may explain the ability of IL-10 to suppress T(H)1 development. Murine immune responses to L. monocytogenes in vivo are of the appropriate T(H)1 phenotype. Therefore, this regulatory pathway may have evolved to enable innate immune cells, through interactions with microbial pathogens, to direct development of specific immunity toward the appropriate T(H) phenotype.