The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen
The Elegance of Sonic Hedgehog: Emerging Novel Functions for a Classic Morphogen
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DOI：
10.1523/jneurosci.1662-18.2018
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发表时间：
2018-10-31
影响因子：
5.3
通讯作者：
Ihrie, Rebecca A.
中科院分区：
文献类型：
--
作者：
Garcia, A. Denise R.;Han, Young-Goo;Ihrie, Rebecca A.
Sonic Hedgehog (SHH) 信号传导以其在胚胎形态发生过程中指定区域和细胞类型身份的作用而广为人知。这篇小型评论是与 2018 年 SFN 小型研讨会同期进行的，该研讨会讨论了一个新兴的研究机构，重点是了解 Shh 信号在神经发育的各种背景下以及最近在成熟的中枢神经系统中的不同作用。此类研究表明，Shh 影响大脑回路的功能，包括多种细胞类型的产生和维持以及线路特异性的建立。在这里，我们回顾这些新颖和意想不到的功能，以及有关 SHH 及其信号通路成员在这些情况下的作用的未解答的问题。
Sonic Hedgehog (SHH) signaling has been most widely known for its role in specifying region and cell-type identity during embryonic morphogenesis. This mini-review accompanies a 2018 SFN mini-symposium that addresses an emerging body of research focused on understanding the diverse roles for Shh signaling in a wide range of contexts in neurodevelopment and, more recently, in the mature CNS. Such research shows that Shh affects the function of brain circuits, including the production and maintenance of diverse cell types and the establishment of wiring specificity. Here, we review these novel and unexpected functions and the unanswered questions regarding the role of SHH and its signaling pathway members in these cases.