The cellular composition of the human immune system is shaped by age and cohabitation.
The cellular composition of the human immune system is shaped by age and cohabitation.
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DOI：
10.1038/ni.3371
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发表时间：
2016-04
影响因子：
30.5
通讯作者：
Liston A
中科院分区：
文献类型：
--
作者：
Carr EJ;Dooley J;Garcia-Perez JE;Lagou V;Lee JC;Wouters C;Meyts I;Goris A;Boeckxstaens G;Linterman MA;Liston A
最近，对人类免疫系统的人群水平的详细描述已经成为可能。我们使用“系统水平”的方法来建立670个健康个体的细胞免疫谱资源。我们报告了一个高水平的个体间的变化，低的纵向变化，在免疫系统的细胞亚群组成的水平。尽管抗原暴露对个体抗原特异性克隆有深远的影响，但细胞亚群结构被证明具有高度弹性，短暂的疫苗接种诱导的变化随后返回到个体的独特基线。引人注目的是，对免疫变异影响最大的是同居，与更广泛的人群相比，共享环境（父母）的个体之间的免疫变异减少了50%。这些结果表明，局部环境条件是人类免疫系统的关键塑造者。
Detailed population-level description of the human immune system has recently become achievable. We used a “systems-level” approach to establish a resource of cellular immune profiles of 670 healthy individuals. We report a high level of inter-individual variation, with low longitudinal variation, at the level of cellular subset composition of the immune system. Despite the profound effects of antigen exposure on individual antigen-specific clones, the cellular subset structure proved highly elastic, with transient vaccination-induced changes being followed by a return to the unique baseline of the individual. Strikingly, the largest influence on immunological variation identified was cohabitation, with a 50% reduction in immunological variation between individuals who share an environment (parents) compared to the wider population. These results identify local environmental conditions are a key shaper of the human immune system.