Metabolic Fatty Liver Disease in Children: A Growing Public Health Problem.
Metabolic Fatty Liver Disease in Children: A Growing Public Health Problem.
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DOI：
10.3390/biomedicines9121915
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发表时间：
2021-12-14
期刊：
影响因子：
4.7
通讯作者：
Gual P
中科院分区：
文献类型：
--
作者：
Le Garf S;Nègre V;Anty R;Gual P
代谢性相关脂肪性肝病（MAFLD），以前称为非酒精性脂肪性肝病（NAFLD），是世界范围内慢性肝病的最重要原因之一，并可能在未来几十年成为终末期肝病的主要原因。MAFLD涵盖了一系列肝脏疾病，从脂肪肝到非酒精性脂肪性肝炎（NASH）、肝纤维化/肝硬化和肝细胞癌。重要的是，儿童期超重和肥胖的发病率不断上升，从1975年的4%上升到2016年的18%，并且肥胖并发症持续存在于成年期，这可能会增加早期严重mald的发病率，从而造成危害。目前，mald是儿童和青少年慢性肝病的主要形式，全球患病率为3%至10%，因此指出早期诊断至关重要。在这篇综述中，我们重点介绍了目前关于儿童MAFLD的流行病学、危险因素、潜在致病机制以及诊断和治疗方法的知识。
Metabolic-associated fatty liver disease (MAFLD), previously called nonalcoholic fatty liver diseases (NAFLD), is one of the most important causes of chronic liver disease worldwide and will likely become the leading cause of end-stage liver disease in the decades ahead. MAFLD covers a continuum of liver diseases from fatty liver to nonalcoholic steatohepatitis (NASH), liver fibrosis/cirrhosis and hepatocellular cancer. Importantly, the growing incidence of overweight and obesity in childhood, 4% in 1975 to 18% in 2016, with persisting obesity complications into adulthood, is likely to be harmful by increasing the incidence of severe MAFLD at an earlier age. Currently, MAFLD is the leading form of chronic liver disease in children and adolescents, with a global prevalence of 3 to 10%, pointing out that early diagnosis is therefore crucial. In this review, we highlight the current knowledge concerning the epidemiology, risk factors and potential pathogenic mechanisms, as well as diagnostic and therapeutic approaches, of pediatric MAFLD.
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影响因子：
24.5
作者：
Feldstein AE;Charatcharoenwitthaya P;Treeprasertsuk S;Benson JT;Enders FB;Angulo P
通讯作者：
Angulo P
影响因子：
3.8
作者：
Carriere, Caroline;Thibault, Helene;Tauber, Maithe
通讯作者：
Tauber, Maithe
影响因子：
11.1
作者：
Dongiovanni P;Stender S;Pietrelli A;Mancina RM;Cespiati A;Petta S;Pelusi S;Pingitore P;Badiali S;Maggioni M;Mannisto V;Grimaudo S;Pipitone RM;Pihlajamaki J;Craxi A;Taube M;Carlsson LMS;Fargion S;Romeo S;Kozlitina J;Valenti L
通讯作者：
Valenti L
影响因子：
8.2
作者：
通讯作者：
--
影响因子：
--
作者：
Castillo-Leon E;Cioffi CE;Vos MB
通讯作者：
Vos MB