Worry is associated with robust reductions in heart rate variability: a transdiagnostic study of anxiety psychopathology.
Worry is associated with robust reductions in heart rate variability: a transdiagnostic study of anxiety psychopathology.
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DOI：
10.1186/s40359-016-0138-z
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发表时间：
2016-06-03
期刊：
影响因子：
3.6
通讯作者：
Quintana DS
中科院分区：
文献类型：
--
作者：
Chalmers JA;Heathers JA;Abbott MJ;Kemp AH;Quintana DS
焦虑症患者的静息心率变异性（HRV）降低，尽管研究结果相互矛盾，具体症状的作用也不太清楚。这是可能的，心率变异性降低可能超越诊断类别，符合精神病理学的维度-特质模型。在这里，我们调查了焦虑症或焦虑，压力，担忧和抑郁的症状是否与静息状态HRV更密切相关。计算了临床焦虑参与者（n = 25）和健康对照组（n = 58）的静息状态HRV。无论诊断如何，也从参与者中收集了担忧，焦虑，压力和抑郁的症状严重程度测量。符合DSM-IV焦虑障碍标准的参与者显示HRV降低，差异具有趋势水平显著性（p = 0.1，Hedges' g =-0.37，BF 10 = 0.84）。高焦虑者（总人数n = 41; n = 22诊断为焦虑症，n = 19不符合任何精神病理学标准）相对于低焦虑者显示静息状态HRV显著降低（p = 0.001，Hedges' g =-0.75，BF 10 = 28.16）。焦虑的特定症状-而不是焦虑症的诊断-与HRV最强烈的降低相关，表明HRV可能提供了焦虑的跨诊断生物标志物。这些结果增强了对心脏自主神经系统和焦虑精神病理学之间关系的理解，为与研究领域标准框架一致的维度-特质模型提供了支持。本文的在线版本（doi：10.1186/s40359-016-0138-z）包含补充材料，可供授权用户使用。
Individuals with anxiety disorders display reduced resting-state heart rate variability (HRV), although findings have been contradictory and the role of specific symptoms has been less clear. It is possible that HRV reductions may transcend diagnostic categories, consistent with dimensional-trait models of psychopathology. Here we investigated whether anxiety disorders or symptoms of anxiety, stress, worry and depression are more strongly associated with resting-state HRV. Resting-state HRV was calculated in participants with clinical anxiety (n = 25) and healthy controls (n = 58). Symptom severity measures of worry, anxiety, stress, and depression were also collected from participants, regardless of diagnosis. Participants who fulfilled DSM-IV criteria for an anxiety disorder displayed diminished HRV, a difference at trend level significance (p = .1, Hedges’ g = -.37, BF10 = .84). High worriers (Total n = 41; n = 22 diagnosed with an anxiety disorder and n = 19 not meeting criteria for any psychopathology) displayed a robust reduction in resting state HRV relative to low worriers (p = .001, Hedges’ g = -.75, BF10 = 28.16). The specific symptom of worry – not the diagnosis of an anxiety disorder – was associated with the most robust reductions in HRV, indicating that HRV may provide a transdiagnostic biomarker of worry. These results enhance understanding of the relationship between the cardiac autonomic nervous system and anxiety psychopathology, providing support for dimensional-trait models consistent with the Research Domain Criteria framework. The online version of this article (doi:10.1186/s40359-016-0138-z) contains supplementary material, which is available to authorized users.