Predicting Aversive Events and Terminating Fear in the Mouse Anterior Cingulate Cortex during Trace Fear Conditioning
Predicting Aversive Events and Terminating Fear in the Mouse Anterior Cingulate Cortex during Trace Fear Conditioning
复制标题
DOI：
10.1523/jneurosci.5566-11.2012
复制
发表时间：
2012-01-18
影响因子：
5.3
通讯作者：
Zhuo, Min
中科院分区：
文献类型：
--
作者：
Steenland, Hendrik W.;Li, Xiang-Yao;Zhuo, Min
许多研究表明，前扣带回皮质(ACC)与恐惧有关，包括恐惧记忆的永久储存。最近的药理学和遗传学研究表明，ACC中的早期突触可塑性也可能有助于在早期时间点进行某些形式的恐惧记忆。然而，还没有研究直接检测自由行为小鼠在早期学习过程中ACC神经元活动的可能变化。在本研究中，我们研究了在痕迹恐惧条件反射过程中ACC的神经反应。我们发现，ACC假定的锥体和非锥体神经元参与了恐惧行为的终止(“解冻”)，这些神经元的尖峰活动在冰冻过程中降低。一些神经元也被发现获得了解冻的锁定活动并改变了它们的调谐。这一结果表明，ACC神经元参与恐惧的学习和控制恐惧行为的消除。我们还表明，在追踪恐惧范式中，ACC对于建立与线索相关的恐惧记忆联系非常重要，这一点通过音调诱发电位和单位活动来衡量。总而言之，我们的发现表明，ACC参与预测未来的厌恶事件，并在痕迹恐惧期间终止恐惧。
A variety of studies have implicated the anterior cingulate cortex (ACC) in fear, including permanent storage of fear memory. Recent pharmacological and genetic studies indicate that early synaptic plasticity in the ACC may also contribute to certain forms of fear memory at early time points. However, no study has directly examined the possible changes in neuronal activity of ACC neurons in freely behaving mice during early learning. In the present study, we examined the neural responses of the ACC during trace fear conditioning. We found that ACC putative pyramidal and nonpyramidal neurons were involved in the termination of fear behavior ("un-freezing"), and the spike activity of these neurons was reduced during freezing. Some of the neurons were also found to acquire un-freezing locked activity and change their tuning. The results implicate the ACC neurons in fear learning and controlling the abolition of fear behavior. We also show that the ACC is important for making cue-related fear memory associations in the trace fear paradigm as measured with tone-evoked potentials and single-unit activity. Collectively, our findings indicate that the ACC is involved in predicting future aversive events and terminating fear during trace fear.