Research progress on the pathogenesis and therapeutics of renal fibrosis
Research progress on the pathogenesis and therapeutics of renal fibrosis
复制标题
DOI：
--
复制
发表时间：
2008
影响因子：
--
通讯作者：
Hu Zhuo-wei
中科院分区：
文献类型：
--
作者：
Hu Zhuo-wei
肾纤维化是慢性肾脏疾病导致慢性肾功能衰竭的常见后果。肾纤维化的病理特征是细胞外基质不成比例地积聚，取代肾实质，最终导致肾脏破坏和功能障碍。肾纤维化涉及多种途径，如炎症、肾细胞凋亡、免疫细胞浸润、氧化应激和细胞因子重定位失衡。本文就肾纤维化的发病机制、新的靶点和有前景的治疗策略的研究进展作一综述。
Renal fibrosis is a common consequence of chronic kidney diseases that leads to chronic renal failure.The pathological characteristics of renal fibrosis is disproportionate accumulation of extracellular matrix that replaces kidney parenchyma,ultimately leading to renal destruction and dysfunction.Several pathways are involved in renal fibrosis,such as inflammation,apoptosis of renal cells,infiltrated immune cells,oxide stress and imbalance of relocated cytokines.Here,we review the pathogenesis of renal fibrosis,and research progress in the novel targets and promising therapeutic strategies.