Former Hand Territory Activity Increases After Amputation During Intact Hand Movements, but Is Unaffected by Illusory Visual Feedback
Former Hand Territory Activity Increases After Amputation During Intact Hand Movements, but Is Unaffected by Illusory Visual Feedback
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DOI：
10.1177/1545968311429687
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发表时间：
2012-07-01
影响因子：
4.2
通讯作者：
Frey, Scott H.
中科院分区：
文献类型：
--
作者：
Bogdanov, Sergei;Smith, Jolinda;Frey, Scott H.
背景。在健康的成年人中，手动运动主要由对侧原发性运动皮层控制。然而，截肢后，完整的手的运动伴随着两个脑半球的感觉运动皮层的活性增加。客观的。作者测试了完整手的使用是否重新激活了以前致力于现在缺失的皮质领土，以及是否可以通过运动图像（MI）（MI）和/或暴露于缺席的手的虚幻视觉“反馈”（VF）来增强这些影响用镜子创建。方法。功能磁共振成像（fMRI）用于描述健康对照中规范性感觉运动的边界。记录了11个单侧手动截距的大脑活动，而他们在4条条件下用完整的手进行听觉节奏的拇指手指测序运动：（1）单独执行完整的手（me），（2）我用相应的mi截肢的手，（3）我用截肢的手VF，以及（4）我用Mi和Vf。结果。在所有条件下，完整的手势运动在以前的感觉运动手部区域内特别增加了活性，这种作用可能归因于截肢后半球间抑制和/或依赖性功能重组的水平降低。通过添加截肢手的VF和/或MI显着增加了这种效果。但是，在截肢者中，MI与这种同侧反应扩展到顶叶，前和预设运动区域有关。结论。完整的手的积极参与可能对于寻求刺激以前的领土的疗法至关重要。
Background. In healthy adults, hand movements are controlled largely by the contralateral primary motor cortex. Following amputation, however, movements of the intact hand are accompanied by increased activity in the sensorimotor cortices of both cerebral hemispheres. Objective. The authors tested whether use of the intact hand reactivates the cortical territory formerly devoted to the now missing hand and whether these effects can be augmented by motor imagery (MI) and/or exposure to illusory visual "feedback" (VF) of the absent hand created with a mirror. Methods. Functional magnetic resonance imaging (fMRI) was used to delineate the boundaries of normative sensorimotor hand representations in healthy controls. Brain activity from 11 unilateral hand amputees was recorded while they performed aurally paced thumb-finger sequencing movements with their intact hands under 4 conditions: (1) motor execution of the intact hand alone (ME), (2) ME with corresponding MI of the amputated hand, (3) ME with VF of the amputated hand, and (4) ME with MI and VF. Results. Intact hand movements increased activity specifically within the former sensorimotor hand territory during all conditions, an effect that may be attributable to decreased levels of interhemispheric inhibition and/or use-dependent functional reorganization following amputation. This effect was not significantly increased by the addition of VF and/or MI of the amputated hand. However, in amputees, MI was associated with an expansion of this ipsilateral response into parietal, premotor, and presupplementary motor areas. Conclusion. Active engagement of the intact hand may be critical for therapies seeking to stimulate the former hand territory.