Prefrontal cortex and basal ganglia control access to working memory
Prefrontal cortex and basal ganglia control access to working memory
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DOI：
10.1038/nn2024
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发表时间：
2008-01-01
影响因子：
25
通讯作者：
Klingberg, Torkel
中科院分区：
文献类型：
--
作者：
McNab, Fiona;Klingberg, Torkel
我们在工作记忆中储存信息的能力可能取决于只记住相关信息的程度。问题仍然是如何选择要记住的相关项目是完成的。在这里，我们发现前额叶皮层和基底神经节的活动先于无关信息的过滤，而这种活动，特别是苍白球的活动，预测了只存储相关信息的程度。前额叶和基底神经节的活动也与工作记忆容量的个体差异有关。这些发现揭示了额叶和基底神经节活动对人类顶叶皮层工作记忆存储的注意控制机制，并对工作记忆容量的个体差异做出了重要贡献。
Our capacity to store information in working memory might be determined by the degree to which only relevant information is remembered. The question remains as to how this selection of relevant items to be remembered is accomplished. Here we show that activity in the prefrontal cortex and basal ganglia preceded the filtering of irrelevant information and that activity, particularly in the globus pallidus, predicted the extent to which only relevant information is stored. The preceding frontal and basal ganglia activity were also associated with inter-individual differences in working memory capacity. These findings reveal a mechanism by which frontal and basal ganglia activity exerts attentional control over access to working memory storage in the parietal cortex in humans, and makes an important contribution to inter-individual differences in working memory capacity.