The Establishment of the First Cancer Tissue Biobank at a Hispanic-Serving Institution: A National Cancer Institute-Funded Initiative between Moffitt Cancer Center in Florida and the Ponce School of Medicine and Health Sciences in Puerto Rico.
The Establishment of the First Cancer Tissue Biobank at a Hispanic-Serving Institution: A National Cancer Institute-Funded Initiative between Moffitt Cancer Center in Florida and the Ponce School of Medicine and Health Sciences in Puerto Rico.
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在西班牙裔服务机构建立第一个癌症组织生物库：佛罗里达州莫菲特癌症中心和波多黎各庞塞医学与健康科学学院之间由国家癌症研究所资助的一项计划。
DOI：
10.1089/bio.2011.0028
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发表时间：
2011
影响因子：
1.6
通讯作者：
Coppola,Domenico
中科院分区：
文献类型：
--
作者：
Flores,Idhaliz;Muñoz-Antonia,Teresita;Matta,Jaime;García,Miosotis;Fenstermacher,David;Gutierrez,Sylvia;Seijo,Edward;Torres-Ruiz,Jose';Pledger,WJack;Coppola,Domenico
以人口为基础的研究对于解决人口之间健康差距的新问题很重要。佛罗里达州的莫菲特癌症中心(MCC)和波多黎各的庞塞医学与健康科学学院(PSMHS)之间的伙伴关系(PSMHS-MCC伙伴关系)是在国家癌症研究所的资助下建立的，目的是促进以岛上和大陆的波多黎各人口为重点的高质量研究、培训和社区推广。我们在这里报告在PSMHS建立一个组织生物库，仿照MCC组织生物库，以支持针对这一少数群体的翻译研究项目。波多黎各组织生物库是由两个机构的基础和临床科学家团队与组织应计部位的管理人员和临床教师密切合作共同开发的。介绍了在波多黎各建立第一个功能齐全的癌症相关生物库所需的努力和需要克服的挑战，并确保其不断发展以满足这一服务不足的拉美裔人口的新需求。由于PSMHS和MCC之间的合作努力，成功地建立了组织采购算法，以获取、处理、存储和进行癌症相关生物显微镜及其相关临床病理数据的病理分析，这些数据来自于在三级医院招募的波多黎各癌症患者。所有方案都符合标准操作程序，以确保生物材料的高质量和患者的机密性。这里描述的过程提供了一种模型，可以应用于在类似的环境下实现功能生物库的建立。
Population-based studies are important to address emerging issues in health disparities among populations. The Partnership between the Moffitt Cancer Center (MCC) in Florida and the Ponce School of Medicine and Health Sciences (PSMHS) in Puerto Rico (the PSMHS-MCC Partnership) was developed to facilitate high-quality research, training, and community outreach focusing on the Puerto Rican population in the island and in the mainland, with funding from the National Cancer Institute. We report here the establishment of a Tissue Biobank at PSMHS, modeled after the MCC tissue biorepository, to support translational research projects on this minority population. This facility, the Puerto Rico Tissue Biobank, was jointly developed by a team of basic and clinical scientists from both institutions in close collaboration with the administrators and clinical faculty of the tissue accrual sites. The efforts required and challenges that needed to be overcome to establish the first functional, centralized cancer-related biobank in Puerto Rico, and to ensure that it continuously evolves to address new needs of this underserved Hispanic population, are described. As a result of the collaborative efforts between PSMHS and MCC, a tissue procurement algorithm was successfully established to acquire, process, store, and conduct pathological analyses of cancer-related biospecimens and their associated clinical-pathological data from Puerto Rican patients with cancer recruited at a tertiary hospital setting. All protocols in place are in accordance with standard operational procedures that ensure high quality of biological materials and patient confidentiality. The processes described here provide a model that can be applied to achieve the establishment of a functional biobank in similar settings.