Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study
Antisaccades and executive dysfunction in early drug-naive Parkinson's disease: The discovery study
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DOI：
10.1002/mds.26134
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发表时间：
2015-05-01
影响因子：
8.6
通讯作者：
Hu, Michele T.
中科院分区：
文献类型：
--
作者：
Antoniades, Chrystalina A.;Demeyere, Nele;Hu, Michele T.
认知障碍在帕金森病（PD）中得到了广泛的认识，但何时开始发展尚不清楚。本研究的目的是在新诊断的未经药物治疗的PD患者中识别认知障碍的早期迹象以及跳眼行为的异常。方法对19例PD患者和20例对照者进行了一系列测试，包括抗扫视任务、语音和语义流畅性、转换和规则发现任务。结果两组在简单任务上无差异。然而，两组的认知表现在更复杂的任务中出现分歧，独立于pd相关的运动损伤。在任务转换测试中，患者表现出较高的抗跳差错误率和转换成本，在规则寻找任务中表现明显较差。结论新诊断帕金森病患者的某些认知领域和跳眼参数在开始用药前就已经明显贫乏。(c) 2015年国际帕金森和运动障碍学会
BackgroundCognitive impairment is well recognized in Parkinson's disease (PD), but when it begins to develop is unclear. The aim of this study was to identify early signs of cognitive impairment along with abnormalities in saccadic behavior in newly diagnosed unmedicated PD patients.MethodsNineteen drug-naive PD patients and 20 controls were examined using a battery of tests, including an antisaccade task, phonemic and semantic verbal fluencies, and a switching and rule finding task.ResultsWith simple tasks, no differences were found between the two groups. However, cognitive performance of the two groups diverged with more complex tasks, occurring independently of PD-related motor impairment. Patients exhibited higher antisaccadic error rates and switch costs in the task switching test, and performed significantly worse in the rule finding task.ConclusionsCertain cognitive domains and saccadic parameters are already significantly impoverished in newly diagnosed Parkinson's patients, even before the initiation of medication. (c) 2015 International Parkinson and Movement Disorder Society