Disruption of Amyloid‐Derived Peptide Assemblies through the Controlled Induction of a β‐Sheet to α‐Helix Transformation: Application of the Switch Concept
Disruption of Amyloid‐Derived Peptide Assemblies through the Controlled Induction of a β‐Sheet to α‐Helix Transformation: Application of the Switch Concept
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DOI：
10.1002/anie.200603681
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发表时间：
2007-04
影响因子：
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通讯作者：
R. Mimna;M. Camus;A. Schmid;G. Tuchscherer;H. Lashuel;M. Mutter
中科院分区：
文献类型：
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作者：
R. Mimna;M. Camus;A. Schmid;G. Tuchscherer;H. Lashuel;M. Mutter
通过控制诱导β折叠转化为溶胶抑制淀粉样蛋白形成。通过使用开关元件S来研究α-螺旋结构可能对理解淀粉样蛋白形成和清除的机制具有重要的意义。
Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and clearance.