Polymerization of a peptide-based enzyme substrate
Polymerization of a peptide-based enzyme substrate
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DOI：
10.1039/c3cc40472b
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发表时间：
2013-01-01
影响因子：
4.9
通讯作者：
Gianneschi, Nathan C.
中科院分区：
文献类型：
--
作者：
Hahn, Michael E.;Randolph, Lyndsay M.;Gianneschi, Nathan C.
采用开环复分解聚合（ROMP）法制备了降冰片烯基修饰肽基酶底物聚合物。显示在水溶性均聚物上的多肽保留了被疾病相关酶酶化处理的能力。相反，当肽被密集地排列在由自组装的两亲嵌段共聚物衍生的纳米颗粒上时，它们作为酶底物的活性降低。
Polymers of norbornenyl-modified peptide-based enzyme substrates have been prepared via ring-opening metathesis polymerization (ROMP). Peptides displayed on water-soluble homopolymers retain the ability to be enzymatically processed by a disease-associated enzyme. In contrast, when the peptides are densely arrayed on a nanoparticle derived from a self-assembled amphiphilic block-copolymer, they function with reduced activity as enzymatic substrates.